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• W2231574872 abstract "Summary (150 words maximum) HIV-associated sensory neuropathy (SN) is the most frequent manifestation of HIV disease, afflicting 40–50% of patients whose HIV disease is otherwise controlled by antiretroviral therapy. It often presents with significant neuropathic pain and is consistently associated with previous exposure to nucleoside reverse transcriptase inhibitors including stavudine, which is widely used in resource-limited settings. Furthermore, recent studies have suggested that exposure to indinavir, a protease inhibitor commonly used as a part of the antiretroviral therapy, is also associated with high prevalence of HIV-SN. Previous work mainly used a single i.v. injection which may not be optimal or repeated i.p. injections over 3 weeks which produce stress on the animals. This protocol describes a refined drug administration procedure carried out to induce antiretroviral drugs stavudine and indinavir induced peripheral SN," @default.
• W2231574872 created "2016-06-24" @default.
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• W2231574872 date "2015-04-10" @default.
• W2231574872 modified "2023-09-27" @default.
• W2231574872 title "Refined rat models of HIV antiretroviral drugs stavudine and indinavir induced peripheral neuropathy" @default.
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• W2231574872 doi "https://doi.org/10.6084/m9.figshare.1373649.v1" @default.
• W2231574872 hasPublicationYear "2015" @default.
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