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- W2231590221 endingPage "F606" @default.
- W2231590221 startingPage "F596" @default.
- W2231590221 abstract "Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream targets as ideal therapeutic strategies. However, pharmacological blockade of TGF-β has not yet translated into successful therapy for humans, which may be due to pleiotropic effects of TGF-β signaling. Equally, TGF-β signaling as a protective response in kidney injury has been relatively underexplored. An emerging body of evidence from experimental kidney disease models indicates multifunctionality of TGF-β capable of inducing profibrotic and protective effects. This review discusses recent advances highlighting the diverse roles of TGF-β in promoting not only renal fibrosis but also protective responses of TGF-β signaling. We review, in particular, growing evidence that supports protective effects of TGF-β by mechanisms which include inhibiting inflammation and induction of autophagy. Additional detailed studies are required to fully understand the diverse mechanisms of TGF-β actions in renal fibrosis and inflammation that will likely direct toward effective antifibrotic therapies." @default.
- W2231590221 created "2016-06-24" @default.
- W2231590221 creator A5020032238 @default.
- W2231590221 creator A5022419005 @default.
- W2231590221 creator A5044179081 @default.
- W2231590221 date "2016-04-01" @default.
- W2231590221 modified "2023-10-14" @default.
- W2231590221 title "TGF-β signaling in the kidney: profibrotic and protective effects" @default.
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