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- W2231624647 abstract "Prostate-specific antigen (PSA) is a serine protease, first identified in 1970 (1) and nowadays widely used for early detection and monitoring of prostate cancer (2). Although previously thought to be produced exclusively by the epithelial cells of the prostate (3), at present PSA is considered a widespread biochemical marker produced and secreted in several biological fluids, by both normal and tumor tissues (e.g., (4)(5)(6)(7)(8)(9)(10)(11)(12)). In blood, complexes form between PSA and serine protease inhibitors, such as α1-antichymotrypsin and α2-macroglobulin (2)(3)(4). Free PSA also exists in serum, even though its increased concentration in female serum is a matter of recent debate (12)(13)(14)(15)(16).Considering the immunoreactivity of PSA in tumors of the lung (7)(8), we undertook the study of the PSA distribution and expression in pleural effusions collected from 68 women, ages 60 ± 11 years.The present work was …" @default.
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- W2231624647 date "1997-05-01" @default.
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- W2231624647 title "Immunoreactive Prostate-Specific Antigen in Pleural Effusions" @default.
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- W2231624647 doi "https://doi.org/10.1093/clinchem/43.5.847" @default.
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