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• W2232209484 abstract "We identified a novel short (s-) mRNA of the human leukotriene-A4 (LTA4) hydrolase using sequential reverse transcriptase PCR mapping. The s-mRNA is generated by skipping an 83 bp exon located in the 3´ coding region and suggests the expression of an LTA4 hydrolase isoform with a calculated molecular mass of 59 kDa and a distinct C-terminus. Both LTA4 hydrolase mRNAs are constitutively expressed in blood cells, endothelial cells, smooth muscle cells, fibroblasts and tumour cells. The ratios of their mRNA expression levels are cell specific, with relatively high s-form mRNA expression in reticulocytes. Our data strongly suggest that the novel mRNA codes for the structurally related but distinct LTA4 hydrolase isoenzyme that has been postulated." @default.
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• W2232209484 date "1996-03-15" @default.
• W2232209484 modified "2023-09-27" @default.
• W2232209484 title "The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms" @default.
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• W2232209484 doi "https://doi.org/10.1042/bj3140733" @default.
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