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- W2232242313 abstract "<ns4:p>Recent biological, structural, and technical advances are converging within the HIV-1 vaccine field to harness the power of antibodies for prevention and therapy. Numerous monoclonal antibodies with broad neutralizing activity against diverse HIV-1 isolates have now been identified, revealing at least five sites of vulnerability on the envelope (Env) glycoproteins. While there are practical and technological barriers blocking a clear path from broadly neutralizing antibodies (bNAb) to a protective vaccine, this is not a dead end. Scientists are revisiting old approaches with new technology, cutting new trails through unexplored territory, and paving new roads in the hopes of preventing HIV-1 infection. Other promising avenues to capitalize on the power of bNAbs are also being pursued, such as passive antibody immunotherapy and gene therapy approaches. Moreover, non-neutralizing antibodies have inhibitory activities that could have protective potential, alone or in combination with bNAbs. With a new generation of bNAbs, and a clinical trial that associated antibodies with reduced acquisition, the field is closer than ever to developing strategies to use antibodies against HIV-1.</ns4:p>" @default.
- W2232242313 created "2016-06-24" @default.
- W2232242313 creator A5026220972 @default.
- W2232242313 creator A5058946392 @default.
- W2232242313 date "2016-01-05" @default.
- W2232242313 modified "2023-09-27" @default.
- W2232242313 title "Harnessing the protective potential of HIV-1 neutralizing antibodies" @default.
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- W2232242313 doi "https://doi.org/10.12688/f1000research.7254.1" @default.
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