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• W2232856929 endingPage "767" @default.
• W2232856929 startingPage "756" @default.
• W2232856929 abstract "The maternal and paternal copies of the genome are both required for mammalian development, and this is primarily due to imprinted genes, those that are monoallelically expressed based on parent-of-origin. Typically, this pattern of expression is regulated by differentially methylated regions (DMRs) that are established in the germline and maintained after fertilization. There are a large number of germline DMRs that have not yet been associated with imprinting, and their function in development is unknown. In this study, we developed a genome-wide approach to identify novel imprinted DMRs in the human placenta and investigated the dynamics of these imprinted DMRs during development in somatic and extraembryonic tissues. DNA methylation was evaluated using the Illumina HumanMethylation450 array in 134 human tissue samples, publicly available reduced representation bisulfite sequencing in the human embryo and germ cells, and targeted bisulfite sequencing in term placentas. Forty-three known and 101 novel imprinted DMRs were identified in the human placenta by comparing methylation between diandric and digynic triploid conceptions in addition to female and male gametes. Seventy-two novel DMRs showed a pattern consistent with placental-specific imprinting, and this monoallelic methylation was entirely maternal in origin. Strikingly, these DMRs exhibited polymorphic imprinted methylation between placental samples. These data suggest that imprinting in human development is far more extensive and dynamic than previously reported and that the placenta preferentially maintains maternal germline-derived DNA methylation." @default.
• W2232856929 created "2016-06-24" @default.
• W2232856929 creator A5020067742 @default.
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• W2232856929 date "2016-01-14" @default.
• W2232856929 modified "2023-10-11" @default.
• W2232856929 title "Pervasive polymorphic imprinted methylation in the human placenta" @default.
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• W2232856929 doi "https://doi.org/10.1101/gr.196139.115" @default.
• W2232856929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4889973" @default.
• W2232856929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26769960" @default.
• W2232856929 hasPublicationYear "2016" @default.
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