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- W2232912186 abstract "Immune thrombocytopenic purpura (ITP) is a common acquired autoimmune disorder characterized by a low platelet count caused by antibodies against platelet surface antigens, mostly glycoproteins IIb/IIIa and Ib/IX. ITP can be present as acute (mainly in children 1–7 years old) and chronic (mainly more than 10 years old). Platelet destruction is triggered by antibodies, but complement-mediated lysis and T-cell cytotoxicity could be involved. Disturbance in megakaryocytes maturation and platelet production, as well as apoptosis were also described. ITP is a diagnosis of exclusion. The diagnostic approach is based primarily on clinical history and physical examination. The first indication of ITP is reduction of platelet count without a change in other cell types. Detection of antiplatelet antibody supports an immune nature of the disease rather than contributing to ITP diagnosis. Treatment of ITP includes steroids, IV immunoglobulin, Rho(D)Ig, anti-CD20 antibody, splenectomy, immunosuppressive drugs, and thrombopoietin." @default.
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- W2232912186 date "2008-01-01" @default.
- W2232912186 modified "2023-09-23" @default.
- W2232912186 title "Autoimmune Thrombocytopenic Purpura" @default.
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- W2232912186 doi "https://doi.org/10.1007/978-1-60327-285-8_100" @default.
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