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- W2232912525 abstract "Publisher Summary This chapter reviews how double-strand breaks (DSBs) are formed in nuclear DNA with emphasis on damage caused by ionizing radiation (IR) and chemotherapeutic agents, describes the main pathways for the repair of DSBs in mammalian cells and highlight how understanding the mechanisms of DNA DSB detection and repair can be used to therapeutic advantage. DNA DSBs are considered one of the most cytotoxic forms of DNA damage. They can occur as a result of normal cellular processes as well as exposure to external sources of DNA damage. There are many intracellular and external sources of DSBs. Failure to repair DSBs can lead to genetic disorders, aging, and cancer. On the other hand, DSBs are commonly regarded as the most deleterious lesions responsible for cell killing by IR and several chemotherapeutic agents used to treat cancer. It is important to realize that the term “double-strand break” or DSB covers a diversity of structures with 3' - and 5' -overhanging termini and blunt-ended structures." @default.
- W2232912525 created "2016-06-24" @default.
- W2232912525 creator A5035453779 @default.
- W2232912525 creator A5065812167 @default.
- W2232912525 date "2012-01-01" @default.
- W2232912525 modified "2023-10-17" @default.
- W2232912525 title "DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance" @default.
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