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- W2233041445 abstract "In the past, the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis was often considered to be the main system that regulated childhood growth and, therefore, determined short stature and tall stature. However, findings have now revealed that the GH-IGF-1 axis is just one of many regulatory systems that control chondrogenesis in the growth plate, which is the biological process that drives height gain. Consequently, normal growth in children depends not only on GH and IGF-1 but also on multiple hormones, paracrine factors, extracellular matrix molecules and intracellular proteins that regulate the activity of growth plate chondrocytes. Mutations in the genes that encode many of these local proteins cause short stature or tall stature. Similarly, genome-wide association studies have revealed that the normal variation in height seems to be largely due to genes outside the GH-IGF-1 axis that affect growth at the growth plate through a wide variety of mechanisms. These findings point to a new conceptual framework for understanding short and tall stature that is centred not on two particular hormones but rather on the growth plate, which is the structure responsible for height gain." @default.
- W2233041445 created "2016-06-24" @default.
- W2233041445 creator A5025381333 @default.
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- W2233041445 creator A5056070577 @default.
- W2233041445 date "2015-10-06" @default.
- W2233041445 modified "2023-10-16" @default.
- W2233041445 title "Short and tall stature: a new paradigm emerges" @default.
- W2233041445 cites W1491950503 @default.
- W2233041445 cites W1515190166 @default.
- W2233041445 cites W1584452031 @default.
- W2233041445 cites W181977599 @default.
- W2233041445 cites W188151426 @default.
- W2233041445 cites W1911040445 @default.
- W2233041445 cites W1937218054 @default.
- W2233041445 cites W1967827488 @default.
- W2233041445 cites W1970170800 @default.
- W2233041445 cites W1972845920 @default.
- W2233041445 cites W1972979483 @default.
- W2233041445 cites W1973361468 @default.
- W2233041445 cites W1973419563 @default.
- W2233041445 cites W1975341610 @default.
- W2233041445 cites W1976741790 @default.
- W2233041445 cites W1978506329 @default.
- W2233041445 cites W1980943558 @default.
- W2233041445 cites W1982356906 @default.
- W2233041445 cites W1983467513 @default.
- W2233041445 cites W1984401784 @default.
- W2233041445 cites W1987413186 @default.
- W2233041445 cites W1987591238 @default.
- W2233041445 cites W1991507681 @default.
- W2233041445 cites W1993689983 @default.
- W2233041445 cites W1995001037 @default.
- W2233041445 cites W1996536876 @default.
- W2233041445 cites W1997075099 @default.
- W2233041445 cites W1997316605 @default.
- W2233041445 cites W1997602059 @default.
- W2233041445 cites W1997637607 @default.
- W2233041445 cites W1997954319 @default.
- W2233041445 cites W1999904631 @default.
- W2233041445 cites W2002323883 @default.
- W2233041445 cites W2002913551 @default.
- W2233041445 cites W2003077563 @default.
- W2233041445 cites W2013424464 @default.
- W2233041445 cites W2014810103 @default.
- W2233041445 cites W2015050458 @default.
- W2233041445 cites W2017892126 @default.
- W2233041445 cites W2019922512 @default.
- W2233041445 cites W2022698529 @default.
- W2233041445 cites W2023088545 @default.
- W2233041445 cites W2023340761 @default.
- W2233041445 cites W2024552375 @default.
- W2233041445 cites W2024662626 @default.
- W2233041445 cites W2028291967 @default.
- W2233041445 cites W2033940805 @default.
- W2233041445 cites W2035692569 @default.
- W2233041445 cites W2037894151 @default.
- W2233041445 cites W2039225176 @default.
- W2233041445 cites W2040325305 @default.
- W2233041445 cites W2041110511 @default.
- W2233041445 cites W2041872503 @default.
- W2233041445 cites W2042932723 @default.
- W2233041445 cites W2043267753 @default.
- W2233041445 cites W2043693453 @default.
- W2233041445 cites W2046742890 @default.
- W2233041445 cites W2046972359 @default.
- W2233041445 cites W2048222359 @default.
- W2233041445 cites W2052113944 @default.
- W2233041445 cites W2053784969 @default.
- W2233041445 cites W2055447043 @default.
- W2233041445 cites W2056835799 @default.
- W2233041445 cites W2057333959 @default.
- W2233041445 cites W2058042193 @default.
- W2233041445 cites W2058474497 @default.
- W2233041445 cites W2063176933 @default.
- W2233041445 cites W2066534789 @default.
- W2233041445 cites W2068121966 @default.
- W2233041445 cites W2070580000 @default.
- W2233041445 cites W2072712027 @default.
- W2233041445 cites W2074060367 @default.
- W2233041445 cites W2074611556 @default.
- W2233041445 cites W2076665011 @default.
- W2233041445 cites W2077727595 @default.
- W2233041445 cites W2078784216 @default.
- W2233041445 cites W2079131400 @default.
- W2233041445 cites W2080548729 @default.
- W2233041445 cites W2081771229 @default.
- W2233041445 cites W2083066292 @default.
- W2233041445 cites W2083197990 @default.
- W2233041445 cites W2083883455 @default.
- W2233041445 cites W2084368843 @default.
- W2233041445 cites W2087660608 @default.
- W2233041445 cites W2088659156 @default.
- W2233041445 cites W2091271116 @default.