FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233205187> ?p ?o ?g. }

• W2233205187 endingPage "2001" @default.
• W2233205187 startingPage "1994" @default.
• W2233205187 abstract "Prostate cancer grows under hypoxic conditions. Hypoxia decreases androgen receptor (AR) protein levels. However, the molecular mechanism remains unclear. Here, we report that p62-mediated autophagy degrades AR protein and suppresses apoptosis in prostate cancer LNCaP cells in hypoxia. In LNCaP cells, hypoxia decreased AR at the protein level, but not at the mRNA level. Hypoxia-induced AR degradation was inhibited not only by knockdown of LC3, a key component of the autophagy machinery, but also by knockdown of p62. Depletion of p62 enhanced hypoxia-induced poly(ADP-ribose) polymerase cleavage and caspase-3 cleavage, markers of apoptosis, whereas simultaneous knockdown of p62 and AR suppressed hypoxia-induced apoptosis. Hypoxia increased the formation of a cytosolic p62–AR complex and enhanced sequestration of AR from the nucleus. Formation of this complex was promoted by the increased phosphorylation of serine 403 in the ubiquitin-associated domain of p62 during hypoxia. An antioxidant and an AMP-activated protein kinase (AMPK) inhibitor reduced hypoxia-induced p62 phosphorylation at serine 403 and suppressed hypoxia-induced complex formation between AR and p62. These results demonstrate that hypoxia enhances the complex formation between p62 and AR by promoting phosphorylation of p62 at serine 403, probably through activating AMPK, and that p62-mediated autophagy degrades AR protein for cell survival in hypoxia." @default.
• W2233205187 created "2016-06-24" @default.
• W2233205187 creator A5034155868 @default.
• W2233205187 creator A5037375255 @default.
• W2233205187 creator A5064110639 @default.
• W2233205187 creator A5077816114 @default.
• W2233205187 creator A5084477871 @default.
• W2233205187 date "2015-10-01" @default.
• W2233205187 modified "2023-10-16" @default.
• W2233205187 title "Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia" @default.
• W2233205187 cites W1493048246 @default.
• W2233205187 cites W1675006565 @default.
• W2233205187 cites W1723613868 @default.
• W2233205187 cites W1968662491 @default.
• W2233205187 cites W1971128969 @default.
• W2233205187 cites W1974251566 @default.
• W2233205187 cites W1976634425 @default.
• W2233205187 cites W1978763812 @default.
• W2233205187 cites W1979210353 @default.
• W2233205187 cites W1982883159 @default.
• W2233205187 cites W1983929660 @default.
• W2233205187 cites W1992659717 @default.
• W2233205187 cites W1993643473 @default.
• W2233205187 cites W1994823455 @default.
• W2233205187 cites W2002288000 @default.
• W2233205187 cites W2014918593 @default.
• W2233205187 cites W2015703878 @default.
• W2233205187 cites W2019364582 @default.
• W2233205187 cites W2019677361 @default.
• W2233205187 cites W2022675211 @default.
• W2233205187 cites W2025049761 @default.
• W2233205187 cites W2033746173 @default.
• W2233205187 cites W2035239007 @default.
• W2233205187 cites W2035391125 @default.
• W2233205187 cites W2040222077 @default.
• W2233205187 cites W2041502315 @default.
• W2233205187 cites W2047144539 @default.
• W2233205187 cites W2055359560 @default.
• W2233205187 cites W2060812610 @default.
• W2233205187 cites W2064293531 @default.
• W2233205187 cites W2074824347 @default.
• W2233205187 cites W2075496544 @default.
• W2233205187 cites W2077084538 @default.
• W2233205187 cites W2079580613 @default.
• W2233205187 cites W2081920342 @default.
• W2233205187 cites W2084892560 @default.
• W2233205187 cites W2086429889 @default.
• W2233205187 cites W2087818316 @default.
• W2233205187 cites W2089865526 @default.
• W2233205187 cites W2095454212 @default.
• W2233205187 cites W2096308078 @default.
• W2233205187 cites W2096738869 @default.
• W2233205187 cites W2103628478 @default.
• W2233205187 cites W2103659405 @default.
• W2233205187 cites W2106787323 @default.
• W2233205187 cites W2109034822 @default.
• W2233205187 cites W2109648353 @default.
• W2233205187 cites W2113722195 @default.
• W2233205187 cites W2115742671 @default.
• W2233205187 cites W2117849574 @default.
• W2233205187 cites W2125123150 @default.
• W2233205187 cites W2136294116 @default.
• W2233205187 cites W2138706753 @default.
• W2233205187 cites W2140559258 @default.
• W2233205187 cites W2144522321 @default.
• W2233205187 cites W2149290376 @default.
• W2233205187 cites W2157096314 @default.
• W2233205187 doi "https://doi.org/10.1016/j.cellsig.2015.07.009" @default.
• W2233205187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26186973" @default.
• W2233205187 hasPublicationYear "2015" @default.
• W2233205187 type Work @default.
• W2233205187 sameAs 2233205187 @default.
• W2233205187 citedByCount "22" @default.
• W2233205187 countsByYear W22332051872015 @default.
• W2233205187 countsByYear W22332051872016 @default.
• W2233205187 countsByYear W22332051872017 @default.
• W2233205187 countsByYear W22332051872018 @default.
• W2233205187 countsByYear W22332051872019 @default.
• W2233205187 countsByYear W22332051872020 @default.
• W2233205187 countsByYear W22332051872022 @default.
• W2233205187 crossrefType "journal-article" @default.
• W2233205187 hasAuthorship W2233205187A5034155868 @default.
• W2233205187 hasAuthorship W2233205187A5037375255 @default.
• W2233205187 hasAuthorship W2233205187A5064110639 @default.
• W2233205187 hasAuthorship W2233205187A5077816114 @default.
• W2233205187 hasAuthorship W2233205187A5084477871 @default.
• W2233205187 hasConcept C11960822 @default.
• W2233205187 hasConcept C121608353 @default.
• W2233205187 hasConcept C173396325 @default.
• W2233205187 hasConcept C178790620 @default.
• W2233205187 hasConcept C185592680 @default.
• W2233205187 hasConcept C190283241 @default.
• W2233205187 hasConcept C203522944 @default.
• W2233205187 hasConcept C2779723316 @default.
• W2233205187 hasConcept C2780124434 @default.
• W2233205187 hasConcept C2780192828 @default.
• W2233205187 hasConcept C540031477 @default.
• W2233205187 hasConcept C54355233 @default.

• next