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- W2233295220 abstract "Foramen ovale is a remnant of the fetal circulation that can be found in all newly born infants and that remain open in about a quarter of adults and the presence of a persistent, or patent, foramen ovale, PFO is associated with cryptogenic stroke [ [1] Johansson M.C. Eriksson P. Dellborg M. The significance of patent foramen ovale: a current review of associated conditions and treatment. Int. J. Cardiol. 2009; 134: 17-24 Abstract Full Text Full Text PDF PubMed Scopus (43) Google Scholar ]. In several observational case-series, cohort studies and registries, device closure of PFO is associated with a significantly lower risk of recurrent stroke or transitory ischemia attacks, TIAs. In the three until today published randomized trials this has not been corroborated however [ 2 Furlan A.J. Reisman M. Massaro J. Mauri L. Adams H. Albers G.W. et al. Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N. Engl. J. Med. 2012; 366: 991-999 Crossref PubMed Scopus (806) Google Scholar , 3 Carroll J.D. Saver J.L. Thaler D.E. RESPECT Investigators et al. Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. N. Engl. J. Med. 2013; 368: 1092-1100 Crossref PubMed Scopus (733) Google Scholar , 4 Meier B. Kalesan B. Mattle HP PC Trial Investigators et al. Percutaneous closure of patent foramen ovale in cryptogenic embolism. N. Engl. J. Med. 2013; 368: 1083-1091 Crossref PubMed Scopus (688) Google Scholar ]. Several reasons for this have been stated such as selection of low-risk patients, inadequate size and duration of randomized studies as well as differences in trial design and technology i.e. device used for closure of the PFO." @default.
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- W2233295220 date "2016-03-01" @default.
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- W2233295220 title "Randomized trials of closure of persistent foramen ovale (PFO) vs medical therapy for patients with cryptogenic stroke — Effect of lost-to-follow-up and withdrawal of consent" @default.
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- W2233295220 doi "https://doi.org/10.1016/j.ijcard.2016.01.185" @default.
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