Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233315590> ?p ?o ?g. }
- W2233315590 abstract "Abstract Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatment, involves the use of therapeutic cells supported by a scaffold for regenerating the infarcted area. It is essential to select the appropriate scaffold material; the ideal one should provide a suitable cellular microenvironment, mimic the native myocardium, and allow mechanical and electrical coupling with host tissues. Among available scaffold materials, natural scaffolds are preferable for achieving these purposes because they possess myocardial extracellular matrix properties and structures. Here, we review several natural scaffolds for applications in MI management, with a focus on pre-clinical studies and clinical trials performed to date. We also evaluate scaffolds combined with different cell types and proteins for their ability to promote improved heart function, contractility and neovascularization, and attenuate adverse ventricular remodeling. Although further refinement is necessary in the coming years, promising results indicate that natural scaffolds may be a valuable translational therapeutic option with clinical impact in MI repair." @default.
- W2233315590 created "2016-06-24" @default.
- W2233315590 creator A5037535424 @default.
- W2233315590 creator A5062218482 @default.
- W2233315590 creator A5085294412 @default.
- W2233315590 date "2015-12-01" @default.
- W2233315590 modified "2023-10-02" @default.
- W2233315590 title "In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin’" @default.
- W2233315590 cites W1522672235 @default.
- W2233315590 cites W1570312518 @default.
- W2233315590 cites W1590813072 @default.
- W2233315590 cites W1722301188 @default.
- W2233315590 cites W1871398233 @default.
- W2233315590 cites W1935621924 @default.
- W2233315590 cites W1946558383 @default.
- W2233315590 cites W1965498876 @default.
- W2233315590 cites W1966433278 @default.
- W2233315590 cites W1967401897 @default.
- W2233315590 cites W1967688133 @default.
- W2233315590 cites W1967735289 @default.
- W2233315590 cites W1968255930 @default.
- W2233315590 cites W1968344424 @default.
- W2233315590 cites W1968494621 @default.
- W2233315590 cites W1968853121 @default.
- W2233315590 cites W1968939951 @default.
- W2233315590 cites W1969287140 @default.
- W2233315590 cites W1970665859 @default.
- W2233315590 cites W1970922113 @default.
- W2233315590 cites W1971265729 @default.
- W2233315590 cites W1974388426 @default.
- W2233315590 cites W1975677405 @default.
- W2233315590 cites W1977413720 @default.
- W2233315590 cites W1978788204 @default.
- W2233315590 cites W1979086325 @default.
- W2233315590 cites W1980950023 @default.
- W2233315590 cites W1981421887 @default.
- W2233315590 cites W1984353324 @default.
- W2233315590 cites W1984531561 @default.
- W2233315590 cites W1986789374 @default.
- W2233315590 cites W1987970488 @default.
- W2233315590 cites W1989504369 @default.
- W2233315590 cites W1989885842 @default.
- W2233315590 cites W1991144246 @default.
- W2233315590 cites W1991297065 @default.
- W2233315590 cites W1996376161 @default.
- W2233315590 cites W1996503675 @default.
- W2233315590 cites W2002128589 @default.
- W2233315590 cites W2002282131 @default.
- W2233315590 cites W2002358384 @default.
- W2233315590 cites W2002822009 @default.
- W2233315590 cites W2002898375 @default.
- W2233315590 cites W2003481724 @default.
- W2233315590 cites W2003518401 @default.
- W2233315590 cites W2003956633 @default.
- W2233315590 cites W2005242898 @default.
- W2233315590 cites W2005266202 @default.
- W2233315590 cites W2007279845 @default.
- W2233315590 cites W2008482182 @default.
- W2233315590 cites W2009502535 @default.
- W2233315590 cites W2011272967 @default.
- W2233315590 cites W2013278505 @default.
- W2233315590 cites W2013459705 @default.
- W2233315590 cites W2013840481 @default.
- W2233315590 cites W2014651133 @default.
- W2233315590 cites W2014762318 @default.
- W2233315590 cites W2016763394 @default.
- W2233315590 cites W2018474760 @default.
- W2233315590 cites W2018630085 @default.
- W2233315590 cites W2022336190 @default.
- W2233315590 cites W2022558601 @default.
- W2233315590 cites W2023385232 @default.
- W2233315590 cites W2023962609 @default.
- W2233315590 cites W2023977064 @default.
- W2233315590 cites W2024032776 @default.
- W2233315590 cites W2024282535 @default.
- W2233315590 cites W2025398599 @default.
- W2233315590 cites W2025832438 @default.
- W2233315590 cites W2026100597 @default.
- W2233315590 cites W2028036560 @default.
- W2233315590 cites W2028781040 @default.
- W2233315590 cites W2029134257 @default.
- W2233315590 cites W2030749854 @default.
- W2233315590 cites W2031952260 @default.
- W2233315590 cites W2032479367 @default.
- W2233315590 cites W2032856345 @default.
- W2233315590 cites W2034977028 @default.
- W2233315590 cites W2036463195 @default.
- W2233315590 cites W2036937290 @default.
- W2233315590 cites W2038458960 @default.
- W2233315590 cites W2038671576 @default.
- W2233315590 cites W2038775969 @default.
- W2233315590 cites W2038846258 @default.
- W2233315590 cites W2039497975 @default.
- W2233315590 cites W2041635943 @default.
- W2233315590 cites W2041947745 @default.
- W2233315590 cites W2043423139 @default.
- W2233315590 cites W2043497836 @default.
- W2233315590 cites W2045218007 @default.
- W2233315590 cites W2045384140 @default.
- W2233315590 cites W2045728822 @default.