FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233529118> ?p ?o ?g. }

• W2233529118 endingPage "838" @default.
• W2233529118 startingPage "825" @default.
• W2233529118 abstract "A complex interaction exists between elements of the host innate immune system and viral pathogens. It is essential that the host mount a robust immune response during viral infection and effectively resolve inflammation once the pathogen has been eliminated. Members of the nucleotide-binding domain leucine-rich repeat [NBD-LRR; known as NOD-like receptor (NLR)] family of cytosolic pattern-recognition receptors are essential components of these immunological processes and have diverse functions in the host antiviral immune response. NLRs can be subgrouped based on their general function. The inflammasome-forming subgroup of NLRs are the best-characterized family members, and several have been found to modulate the maturation of IL-1β and IL-18 following virus exposure. However, the members of the regulatory NLR subgroups are significantly less characterized. These NLRs uniquely function to modulate signalling pathways initiated by other families of pattern-recognition receptors, such as Toll-like receptors and/or Rig-I-like helicase receptors. Regulatory NLRs that augment pro-inflammatory pathways include nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2, which have been shown to form a multiprotein complex termed the NODosome that significantly modulates IFN and NF-κB signalling following viral infection. Conversely, a second subgroup of regulatory NLRs functions to negatively regulate inflammation. These inhibitory NLRs include NLRX1, NLRP12 and NLRC3, which have been shown to interact with TRAF molecules and various kinases to modulate diverse cellular processes. Targeting NLR signalling following infection with a virus represents a novel and promising therapeutic strategy. However, significant effort is still required to translate the current understanding of NLR biology into effective therapies." @default.
• W2233529118 created "2016-06-24" @default.
• W2233529118 creator A5008179003 @default.
• W2233529118 creator A5015509350 @default.
• W2233529118 creator A5067570838 @default.
• W2233529118 date "2016-04-01" @default.
• W2233529118 modified "2023-10-16" @default.
• W2233529118 title "Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure" @default.
• W2233529118 cites W1483334228 @default.
• W2233529118 cites W1529674879 @default.
• W2233529118 cites W1536422556 @default.
• W2233529118 cites W1587650589 @default.
• W2233529118 cites W1605880567 @default.
• W2233529118 cites W1642457845 @default.
• W2233529118 cites W1670573097 @default.
• W2233529118 cites W1671630222 @default.
• W2233529118 cites W1745233589 @default.
• W2233529118 cites W1946520978 @default.
• W2233529118 cites W1966132440 @default.
• W2233529118 cites W1968178474 @default.
• W2233529118 cites W1968330834 @default.
• W2233529118 cites W1970072513 @default.
• W2233529118 cites W1970154782 @default.
• W2233529118 cites W1973455657 @default.
• W2233529118 cites W1975032025 @default.
• W2233529118 cites W1978444327 @default.
• W2233529118 cites W1978602689 @default.
• W2233529118 cites W1980539060 @default.
• W2233529118 cites W1983411723 @default.
• W2233529118 cites W1983502509 @default.
• W2233529118 cites W1986619858 @default.
• W2233529118 cites W1987433340 @default.
• W2233529118 cites W1987918710 @default.
• W2233529118 cites W1994490736 @default.
• W2233529118 cites W1995321760 @default.
• W2233529118 cites W1996853331 @default.
• W2233529118 cites W2000023984 @default.
• W2233529118 cites W2000564866 @default.
• W2233529118 cites W2005626121 @default.
• W2233529118 cites W2006278240 @default.
• W2233529118 cites W2009080092 @default.
• W2233529118 cites W2012272570 @default.
• W2233529118 cites W2013999310 @default.
• W2233529118 cites W2015129508 @default.
• W2233529118 cites W2015934540 @default.
• W2233529118 cites W2017094323 @default.
• W2233529118 cites W2018542503 @default.
• W2233529118 cites W2024383625 @default.
• W2233529118 cites W2032661113 @default.
• W2233529118 cites W2034136050 @default.
• W2233529118 cites W2036222092 @default.
• W2233529118 cites W2039010779 @default.
• W2233529118 cites W2040024879 @default.
• W2233529118 cites W2041345682 @default.
• W2233529118 cites W2042288276 @default.
• W2233529118 cites W2042816890 @default.
• W2233529118 cites W2043667001 @default.
• W2233529118 cites W2045743590 @default.
• W2233529118 cites W2046470781 @default.
• W2233529118 cites W2052798287 @default.
• W2233529118 cites W2053847949 @default.
• W2233529118 cites W2060004514 @default.
• W2233529118 cites W2061888854 @default.
• W2233529118 cites W2063492133 @default.
• W2233529118 cites W2065854688 @default.
• W2233529118 cites W2067436737 @default.
• W2233529118 cites W2069747395 @default.
• W2233529118 cites W2069917993 @default.
• W2233529118 cites W2070461642 @default.
• W2233529118 cites W2071496192 @default.
• W2233529118 cites W2077538385 @default.
• W2233529118 cites W2079936328 @default.
• W2233529118 cites W2081359858 @default.
• W2233529118 cites W2083896869 @default.
• W2233529118 cites W2088011208 @default.
• W2233529118 cites W2088807396 @default.
• W2233529118 cites W2089972348 @default.
• W2233529118 cites W2091501729 @default.
• W2233529118 cites W2091596699 @default.
• W2233529118 cites W2096374450 @default.
• W2233529118 cites W2097082261 @default.
• W2233529118 cites W2097714951 @default.
• W2233529118 cites W2098565347 @default.
• W2233529118 cites W2101096291 @default.
• W2233529118 cites W2104472257 @default.
• W2233529118 cites W2105409495 @default.
• W2233529118 cites W2106841351 @default.
• W2233529118 cites W2106855445 @default.
• W2233529118 cites W2108180656 @default.
• W2233529118 cites W2109381735 @default.
• W2233529118 cites W2111686546 @default.
• W2233529118 cites W2111900042 @default.
• W2233529118 cites W2111919009 @default.
• W2233529118 cites W2120766296 @default.
• W2233529118 cites W2121722333 @default.
• W2233529118 cites W2122364835 @default.
• W2233529118 cites W2126826389 @default.
• W2233529118 cites W2132469228 @default.

• next