Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233541949> ?p ?o ?g. }
- W2233541949 endingPage "6" @default.
- W2233541949 startingPage "6" @default.
- W2233541949 abstract "We are presenting a quantitative proteomics tally of the most commonly expressed conserved fungal proteins of the cytosol, the cell wall, and the secretome. It was our goal to identify fungi-typical proteins that do not share significant homology with human proteins. Such fungal proteins are of interest to the development of vaccines or drug targets. Protein samples were derived from 13 fungal species, cultured in rich or in minimal media; these included clinical isolates of Aspergillus, Candida, Mucor, Cryptococcus, and Coccidioides species. Proteomes were analyzed by quantitative MSE (Mass Spectrometry—Elevated Collision Energy). Several thousand proteins were identified and quantified in total across all fractions and culture conditions. The 42 most abundant proteins identified in fungal cell walls or supernatants shared no to very little homology with human proteins. In contrast, all but five of the 50 most abundant cytosolic proteins had human homologs with sequence identity averaging 59%. Proteomic comparisons of the secreted or surface localized fungal proteins highlighted conserved homologs of the Aspergillus fumigatus proteins 1,3-β-glucanosyltransferases (Bgt1, Gel1-4), Crf1, Ecm33, EglC, and others. The fact that Crf1 and Gel1 were previously shown to be promising vaccine candidates, underlines the value of the proteomics data presented here." @default.
- W2233541949 created "2016-06-24" @default.
- W2233541949 creator A5004935906 @default.
- W2233541949 creator A5014273536 @default.
- W2233541949 creator A5021143803 @default.
- W2233541949 creator A5029728911 @default.
- W2233541949 creator A5033656130 @default.
- W2233541949 date "2016-01-12" @default.
- W2233541949 modified "2023-09-26" @default.
- W2233541949 title "Proteomic Analysis of Pathogenic Fungi Reveals Highly Expressed Conserved Cell Wall Proteins" @default.
- W2233541949 cites W1572283658 @default.
- W2233541949 cites W1849607011 @default.
- W2233541949 cites W1938350212 @default.
- W2233541949 cites W1963543261 @default.
- W2233541949 cites W1965287301 @default.
- W2233541949 cites W1966516361 @default.
- W2233541949 cites W1968470724 @default.
- W2233541949 cites W1969599021 @default.
- W2233541949 cites W1970766899 @default.
- W2233541949 cites W1973722179 @default.
- W2233541949 cites W1974047870 @default.
- W2233541949 cites W1974453975 @default.
- W2233541949 cites W1978918412 @default.
- W2233541949 cites W1981536086 @default.
- W2233541949 cites W1983673205 @default.
- W2233541949 cites W1986908111 @default.
- W2233541949 cites W1991568703 @default.
- W2233541949 cites W2001555960 @default.
- W2233541949 cites W2001611920 @default.
- W2233541949 cites W2010165614 @default.
- W2233541949 cites W2011242271 @default.
- W2233541949 cites W2011969822 @default.
- W2233541949 cites W2015652575 @default.
- W2233541949 cites W2018557829 @default.
- W2233541949 cites W2021613526 @default.
- W2233541949 cites W2023422450 @default.
- W2233541949 cites W2023843703 @default.
- W2233541949 cites W2025939946 @default.
- W2233541949 cites W2026927296 @default.
- W2233541949 cites W2027404073 @default.
- W2233541949 cites W2027967242 @default.
- W2233541949 cites W2036799680 @default.
- W2233541949 cites W2037846837 @default.
- W2233541949 cites W2039607959 @default.
- W2233541949 cites W2042497626 @default.
- W2233541949 cites W2042775525 @default.
- W2233541949 cites W2046819854 @default.
- W2233541949 cites W2054380602 @default.
- W2233541949 cites W2055043387 @default.
- W2233541949 cites W2058916934 @default.
- W2233541949 cites W2061198209 @default.
- W2233541949 cites W2071969409 @default.
- W2233541949 cites W2072386149 @default.
- W2233541949 cites W2079928619 @default.
- W2233541949 cites W2079973970 @default.
- W2233541949 cites W2087573245 @default.
- W2233541949 cites W2088327796 @default.
- W2233541949 cites W2090677789 @default.
- W2233541949 cites W2096343569 @default.
- W2233541949 cites W2097493039 @default.
- W2233541949 cites W2098726188 @default.
- W2233541949 cites W2100033891 @default.
- W2233541949 cites W2101877292 @default.
- W2233541949 cites W2102973863 @default.
- W2233541949 cites W2104706766 @default.
- W2233541949 cites W2106364860 @default.
- W2233541949 cites W2107490735 @default.
- W2233541949 cites W2109814431 @default.
- W2233541949 cites W2114101084 @default.
- W2233541949 cites W2116582554 @default.
- W2233541949 cites W2124610014 @default.
- W2233541949 cites W2126421255 @default.
- W2233541949 cites W2129795013 @default.
- W2233541949 cites W2132072403 @default.
- W2233541949 cites W2138426885 @default.
- W2233541949 cites W2138977897 @default.
- W2233541949 cites W2140293306 @default.
- W2233541949 cites W2141197648 @default.
- W2233541949 cites W2144714752 @default.
- W2233541949 cites W2149051930 @default.
- W2233541949 cites W2153797406 @default.
- W2233541949 cites W2158173168 @default.
- W2233541949 cites W2159713325 @default.
- W2233541949 cites W2160049423 @default.
- W2233541949 cites W2166387000 @default.
- W2233541949 cites W2166972217 @default.
- W2233541949 cites W2167246272 @default.
- W2233541949 cites W2168407031 @default.
- W2233541949 cites W2168887693 @default.
- W2233541949 cites W2238717202 @default.
- W2233541949 cites W2265623652 @default.
- W2233541949 cites W2312464115 @default.
- W2233541949 cites W2317943467 @default.
- W2233541949 cites W2321059444 @default.
- W2233541949 cites W2324262342 @default.
- W2233541949 cites W2325431879 @default.
- W2233541949 cites W2337229254 @default.
- W2233541949 cites W2337785792 @default.