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- W2233577420 startingPage "252" @default.
- W2233577420 abstract "Type I interferons (IFN-α/β) are the major components of the innate immune response of hosts, and in turn many viruses have evolved to modulate the host response during infection. We found that the IFN-β production was significantly suppressed during PEDV infection in cells. To identify viral IFN antagonists and to study their suppressive function, viral coding sequences for the entire structural and nonstructural proteins were cloned and expressed. Of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15 and nsp16 were found to inhibit the IFN-β and IRF3 promoter activities. The sole accessory protein ORF3, structure protein envelope (E), membrane (M), and nucleocapsid (N) protein were also shown to inhibit such activities. PEDV nsp1 did not interfere the IRF3 phosphorylation and nuclear translocation but interrupted the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by degrading CBP. A further study showed that the CBP degradation by nsp1 was proteasome-dependent. Our data demonstrate that PEDV modulates the host innate immune responses by degrading CBP and suppressing ISGs expression." @default.
- W2233577420 created "2016-06-24" @default.
- W2233577420 creator A5005850471 @default.
- W2233577420 creator A5032443844 @default.
- W2233577420 creator A5065297741 @default.
- W2233577420 date "2016-02-01" @default.
- W2233577420 modified "2023-10-05" @default.
- W2233577420 title "Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1" @default.
- W2233577420 cites W1491531822 @default.
- W2233577420 cites W1526303449 @default.
- W2233577420 cites W1537233581 @default.
- W2233577420 cites W1537814268 @default.
- W2233577420 cites W1554543951 @default.
- W2233577420 cites W1560860164 @default.
- W2233577420 cites W1884928119 @default.
- W2233577420 cites W1920404179 @default.
- W2233577420 cites W1964626485 @default.
- W2233577420 cites W1965530957 @default.
- W2233577420 cites W1966504197 @default.
- W2233577420 cites W1971274602 @default.
- W2233577420 cites W1971558192 @default.
- W2233577420 cites W1973454407 @default.
- W2233577420 cites W1974963408 @default.
- W2233577420 cites W1976462769 @default.
- W2233577420 cites W1977728069 @default.
- W2233577420 cites W1978799194 @default.
- W2233577420 cites W1979633272 @default.
- W2233577420 cites W1984742686 @default.
- W2233577420 cites W1986361699 @default.
- W2233577420 cites W1989207797 @default.
- W2233577420 cites W1989215732 @default.
- W2233577420 cites W1990565764 @default.
- W2233577420 cites W1991185690 @default.
- W2233577420 cites W1993498022 @default.
- W2233577420 cites W1994942139 @default.
- W2233577420 cites W1995296637 @default.
- W2233577420 cites W1996523417 @default.
- W2233577420 cites W1999050752 @default.
- W2233577420 cites W2001947268 @default.
- W2233577420 cites W200286807 @default.
- W2233577420 cites W2009778495 @default.
- W2233577420 cites W2010232164 @default.
- W2233577420 cites W2011204722 @default.
- W2233577420 cites W2011656809 @default.
- W2233577420 cites W2012504769 @default.
- W2233577420 cites W2014382917 @default.
- W2233577420 cites W2015721404 @default.
- W2233577420 cites W2016452561 @default.
- W2233577420 cites W2016457570 @default.
- W2233577420 cites W2022347066 @default.
- W2233577420 cites W2023033376 @default.
- W2233577420 cites W2023665721 @default.
- W2233577420 cites W2025638633 @default.
- W2233577420 cites W2028401536 @default.
- W2233577420 cites W2029627660 @default.
- W2233577420 cites W2033513617 @default.
- W2233577420 cites W2035494209 @default.
- W2233577420 cites W2040957849 @default.
- W2233577420 cites W2045814444 @default.
- W2233577420 cites W2046505568 @default.
- W2233577420 cites W2047119203 @default.
- W2233577420 cites W2047529506 @default.
- W2233577420 cites W2049924342 @default.
- W2233577420 cites W2050509264 @default.
- W2233577420 cites W2061710365 @default.
- W2233577420 cites W2071680235 @default.
- W2233577420 cites W2073996691 @default.
- W2233577420 cites W2075944727 @default.
- W2233577420 cites W2076787553 @default.
- W2233577420 cites W2077291760 @default.
- W2233577420 cites W2078490133 @default.
- W2233577420 cites W2079255671 @default.
- W2233577420 cites W2084880831 @default.
- W2233577420 cites W2091344524 @default.
- W2233577420 cites W2092463285 @default.
- W2233577420 cites W2094023848 @default.
- W2233577420 cites W2096546138 @default.
- W2233577420 cites W2098103851 @default.
- W2233577420 cites W2098188064 @default.
- W2233577420 cites W2098675796 @default.
- W2233577420 cites W2099635229 @default.
- W2233577420 cites W2100867908 @default.
- W2233577420 cites W2106713698 @default.
- W2233577420 cites W2107277218 @default.
- W2233577420 cites W2111058723 @default.
- W2233577420 cites W2112533943 @default.
- W2233577420 cites W2114174897 @default.
- W2233577420 cites W2116739202 @default.
- W2233577420 cites W2123543951 @default.
- W2233577420 cites W2123669249 @default.
- W2233577420 cites W2124950819 @default.
- W2233577420 cites W2127597058 @default.
- W2233577420 cites W2130576390 @default.
- W2233577420 cites W2132784079 @default.
- W2233577420 cites W2134464188 @default.
- W2233577420 cites W2135248979 @default.
- W2233577420 cites W2135286784 @default.
- W2233577420 cites W2136326235 @default.