FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233621863> ?p ?o ?g. }

• W2233621863 endingPage "8" @default.
• W2233621863 startingPage "1" @default.
• W2233621863 abstract "Rheumatoid arthritis (RA), a chronic systemic autoimmune disease, stimulates various immune cells especially macrophages, causing release of various proinflammatory cytokines such as TNF-α leading to persistent synovitis. Chloroquine, an anti-malarial drug inhibits the production of TNF-α, thus, halting the disease progression. The aim of the present study was fabrication, characterization and demonstration of kinetic and dynamic efficacy of chloroquine loaded solid lipid nanoparticles (CQ-SLNs) in arthritic rats and in lowering TNF-α levels. CQ-SLNs were prepared using melt homogenization method and subjected to lyophilization. The particle size, zeta potential, PDI and entrapment efficiency were found to be 113.6±0.15nm, -27.8±1.21mV, 0.125±0.03 and 93.45±0.43% respectively. Ex vivo endocytic uptake studies revealed engrossment of endocytic pathways in the uptake of SLN from intestine. Plasma drug profile upon pharmacokinetic evaluation demonstrated increased AUC, half-life and decreased elimination rate of the drug. Pharmacodynamic studies revealed reduction in the paw volume, bone erosion and cartilage destruction, the same was also reflected in histopathological studies. The TNF-α ELISA concluded that the TNF-α level was significantly reduced in the synovial fluid upon treatment with CQ-SLN, thus, leading to the conclusion that CQ-SLN could be used as a potential in reducing inflammatory TNF-α at the arthritic site and halting the disease progression." @default.
• W2233621863 created "2016-06-24" @default.
• W2233621863 creator A5013863614 @default.
• W2233621863 creator A5043746481 @default.
• W2233621863 creator A5070657209 @default.
• W2233621863 date "2016-03-01" @default.
• W2233621863 modified "2023-10-13" @default.
• W2233621863 title "Fabrication and efficacy evaluation of chloroquine nanoparticles in CFA-induced arthritic rats using TNF-α ELISA" @default.
• W2233621863 cites W1579046626 @default.
• W2233621863 cites W1858465734 @default.
• W2233621863 cites W1968087101 @default.
• W2233621863 cites W1968720144 @default.
• W2233621863 cites W1972217226 @default.
• W2233621863 cites W1973232910 @default.
• W2233621863 cites W1976878390 @default.
• W2233621863 cites W1984148393 @default.
• W2233621863 cites W2000177666 @default.
• W2233621863 cites W2003110090 @default.
• W2233621863 cites W2012318066 @default.
• W2233621863 cites W2012690250 @default.
• W2233621863 cites W2014044314 @default.
• W2233621863 cites W2017853225 @default.
• W2233621863 cites W2025441457 @default.
• W2233621863 cites W2045260358 @default.
• W2233621863 cites W2046683130 @default.
• W2233621863 cites W2068846148 @default.
• W2233621863 cites W2075446695 @default.
• W2233621863 cites W2099769485 @default.
• W2233621863 cites W2101840353 @default.
• W2233621863 cites W2151175415 @default.
• W2233621863 cites W2151975795 @default.
• W2233621863 doi "https://doi.org/10.1016/j.ejps.2016.01.009" @default.
• W2233621863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26776969" @default.
• W2233621863 hasPublicationYear "2016" @default.
• W2233621863 type Work @default.
• W2233621863 sameAs 2233621863 @default.
• W2233621863 citedByCount "32" @default.
• W2233621863 countsByYear W22336218632017 @default.
• W2233621863 countsByYear W22336218632018 @default.
• W2233621863 countsByYear W22336218632019 @default.
• W2233621863 countsByYear W22336218632020 @default.
• W2233621863 countsByYear W22336218632021 @default.
• W2233621863 countsByYear W22336218632022 @default.
• W2233621863 countsByYear W22336218632023 @default.
• W2233621863 crossrefType "journal-article" @default.
• W2233621863 hasAuthorship W2233621863A5013863614 @default.
• W2233621863 hasAuthorship W2233621863A5043746481 @default.
• W2233621863 hasAuthorship W2233621863A5070657209 @default.
• W2233621863 hasConcept C111113717 @default.
• W2233621863 hasConcept C112705442 @default.
• W2233621863 hasConcept C150903083 @default.
• W2233621863 hasConcept C164027704 @default.
• W2233621863 hasConcept C17991360 @default.
• W2233621863 hasConcept C185592680 @default.
• W2233621863 hasConcept C199529486 @default.
• W2233621863 hasConcept C202751555 @default.
• W2233621863 hasConcept C203014093 @default.
• W2233621863 hasConcept C207001950 @default.
• W2233621863 hasConcept C26291073 @default.
• W2233621863 hasConcept C2776914184 @default.
• W2233621863 hasConcept C2777077863 @default.
• W2233621863 hasConcept C2777575956 @default.
• W2233621863 hasConcept C2780035454 @default.
• W2233621863 hasConcept C55493867 @default.
• W2233621863 hasConcept C71924100 @default.
• W2233621863 hasConcept C86803240 @default.
• W2233621863 hasConcept C98274493 @default.
• W2233621863 hasConceptScore W2233621863C111113717 @default.
• W2233621863 hasConceptScore W2233621863C112705442 @default.
• W2233621863 hasConceptScore W2233621863C150903083 @default.
• W2233621863 hasConceptScore W2233621863C164027704 @default.
• W2233621863 hasConceptScore W2233621863C17991360 @default.
• W2233621863 hasConceptScore W2233621863C185592680 @default.
• W2233621863 hasConceptScore W2233621863C199529486 @default.
• W2233621863 hasConceptScore W2233621863C202751555 @default.
• W2233621863 hasConceptScore W2233621863C203014093 @default.
• W2233621863 hasConceptScore W2233621863C207001950 @default.
• W2233621863 hasConceptScore W2233621863C26291073 @default.
• W2233621863 hasConceptScore W2233621863C2776914184 @default.
• W2233621863 hasConceptScore W2233621863C2777077863 @default.
• W2233621863 hasConceptScore W2233621863C2777575956 @default.
• W2233621863 hasConceptScore W2233621863C2780035454 @default.
• W2233621863 hasConceptScore W2233621863C55493867 @default.
• W2233621863 hasConceptScore W2233621863C71924100 @default.
• W2233621863 hasConceptScore W2233621863C86803240 @default.
• W2233621863 hasConceptScore W2233621863C98274493 @default.
• W2233621863 hasFunder F4320326590 @default.
• W2233621863 hasLocation W22336218631 @default.
• W2233621863 hasLocation W22336218632 @default.
• W2233621863 hasOpenAccess W2233621863 @default.
• W2233621863 hasPrimaryLocation W22336218631 @default.
• W2233621863 hasRelatedWork W1989676936 @default.
• W2233621863 hasRelatedWork W1992848314 @default.
• W2233621863 hasRelatedWork W2092421291 @default.
• W2233621863 hasRelatedWork W2392126385 @default.
• W2233621863 hasRelatedWork W2416795054 @default.
• W2233621863 hasRelatedWork W2621228630 @default.
• W2233621863 hasRelatedWork W2769286742 @default.

• next