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- W2233703041 endingPage "308" @default.
- W2233703041 startingPage "275" @default.
- W2233703041 abstract "Skeletal muscle stem cells known as satellite cells are responsible for muscle regeneration. Upon muscle injury, previously quiescent satellite cells become activated as proliferating myogenic precursors, differentiate into myoblasts, and ultimately fuse into new, multinucleated myofibers. Unfortunately, this paradigm breaks down with aging and instead of becoming activated upon injury, satellite cells remain quiescent. Recent work, however, has shed light on the mechanisms behind this impaired regeneration and these findings suggest several therapeutic avenues. Skeletal muscle tissue engineering aims to create functional muscle in vitro followed by engraftment in vivo for the replacement or repair of missing or pathological tissue in various dystrophies or myopathies. Biomaterials have rapidly become central to these regeneration efforts and numerous repair strategies already exist. However, optimization of these biomaterial platforms in order to more fully mimic the in vivo adult skeletal muscle niche is still necessary. More importantly perhaps, the effects of aged or pathological environments on skeletal muscle engraftment has yet to be fully characterized. Furthermore, debate still remains over whether or not all satellite cells (considered to be heterogeneous in genetic markers and functional properties) are in fact stem cells, and what implications this could have on in vitro regeneration strategies. Novel uses and advances in biomaterials show promise in tackling these problems. Therefore, after a discussion of muscle regeneration in both the ‘young’ and ‘aged’ niches, this chapter will examine the most up-to-date strategies for in vitro skeletal muscle regeneration and will discuss how current efforts in biomaterial technologies might be used to accurately determine the significance of satellite cells as muscle stem cells, and control robust production of myofibers in vitro by mimicking the in vivo niche." @default.
- W2233703041 created "2016-06-24" @default.
- W2233703041 creator A5016353918 @default.
- W2233703041 creator A5058991617 @default.
- W2233703041 date "2010-01-01" @default.
- W2233703041 modified "2023-10-14" @default.
- W2233703041 title "Biomaterial Applications in the Adult Skeletal Muscle Satellite Cell Niche: Deliberate Control of Muscle Stem Cells and Muscle Regeneration in the Aged Niche" @default.
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