Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233729479> ?p ?o ?g. }
- W2233729479 endingPage "89" @default.
- W2233729479 startingPage "89" @default.
- W2233729479 abstract "Squamous Cell Carcinoma-derived Stem-like Cells (SCC-SC) originate from alterations in keratinocyte stem cells (KSC) gene expression and sustain tumor development, invasion and recurrence. Since survivin, a KSC marker, is highly expressed in SCC-SC, we evaluate its role in SCC-SC cell growth and SCC models. Survivin silencing by siRNA decreases clonal growth of SCC keratinocytes and viability of total, rapidly adhering (RAD) and non-RAD (NRAD) cells from primary SCC. Similarly, survivin silencing reduces the expression of stem cell markers (OCT4, NOTCH1, CD133, β1-integrin), while it increases the level of differentiation markers (K10, involucrin). Moreover, survivin silencing improves the malignant phenotype of SCC 3D-reconstruct, as demonstrated by reduced epidermal thickness, lower Ki-67 positive cell number, and decreased expression of MMP9 and psoriasin. Furthermore, survivin depletion by siRNA in RasG12V-IκBα-derived tumors leads to smaller tumor formation characterized by lower mitotic index and reduced expression of the tumor-associated marker HIF1α, VEGF and CD51. Therefore, our results indicate survivin as a key gene in regulating SCC cancer stem cell formation and cSCC development." @default.
- W2233729479 created "2016-06-24" @default.
- W2233729479 creator A5005390178 @default.
- W2233729479 creator A5006526481 @default.
- W2233729479 creator A5006920216 @default.
- W2233729479 creator A5008274065 @default.
- W2233729479 creator A5021374018 @default.
- W2233729479 creator A5024024464 @default.
- W2233729479 creator A5052390682 @default.
- W2233729479 creator A5057459026 @default.
- W2233729479 creator A5063263652 @default.
- W2233729479 creator A5078433399 @default.
- W2233729479 creator A5087627289 @default.
- W2233729479 date "2016-01-12" @default.
- W2233729479 modified "2023-09-26" @default.
- W2233729479 title "Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo" @default.
- W2233729479 cites W1726104989 @default.
- W2233729479 cites W1943633942 @default.
- W2233729479 cites W1966731113 @default.
- W2233729479 cites W1969590960 @default.
- W2233729479 cites W1973019046 @default.
- W2233729479 cites W1981177118 @default.
- W2233729479 cites W1986301169 @default.
- W2233729479 cites W1987814339 @default.
- W2233729479 cites W1994672904 @default.
- W2233729479 cites W1994796945 @default.
- W2233729479 cites W2000477644 @default.
- W2233729479 cites W2004458717 @default.
- W2233729479 cites W2005334224 @default.
- W2233729479 cites W2007713463 @default.
- W2233729479 cites W2012209428 @default.
- W2233729479 cites W2026386784 @default.
- W2233729479 cites W2029675195 @default.
- W2233729479 cites W2044075950 @default.
- W2233729479 cites W2044459199 @default.
- W2233729479 cites W2046345512 @default.
- W2233729479 cites W2049309455 @default.
- W2233729479 cites W2053811330 @default.
- W2233729479 cites W2057624501 @default.
- W2233729479 cites W2062210994 @default.
- W2233729479 cites W2064550239 @default.
- W2233729479 cites W2067175668 @default.
- W2233729479 cites W2077562703 @default.
- W2233729479 cites W2078191682 @default.
- W2233729479 cites W2082373329 @default.
- W2233729479 cites W2083142664 @default.
- W2233729479 cites W2084753863 @default.
- W2233729479 cites W2085461231 @default.
- W2233729479 cites W2085512015 @default.
- W2233729479 cites W2086648858 @default.
- W2233729479 cites W2093999903 @default.
- W2233729479 cites W2098355998 @default.
- W2233729479 cites W2098432933 @default.
- W2233729479 cites W2101602122 @default.
- W2233729479 cites W2102298258 @default.
- W2233729479 cites W2109678171 @default.
- W2233729479 cites W2112702770 @default.
- W2233729479 cites W2116562692 @default.
- W2233729479 cites W2117096641 @default.
- W2233729479 cites W2124462932 @default.
- W2233729479 cites W2128925630 @default.
- W2233729479 cites W2133109532 @default.
- W2233729479 cites W2145768398 @default.
- W2233729479 cites W2154847758 @default.
- W2233729479 cites W2155596560 @default.
- W2233729479 cites W2168995016 @default.
- W2233729479 cites W2170785948 @default.
- W2233729479 cites W2314033044 @default.
- W2233729479 cites W4245093707 @default.
- W2233729479 cites W89281881 @default.
- W2233729479 doi "https://doi.org/10.3390/ijms17010089" @default.
- W2233729479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4730332" @default.
- W2233729479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26771605" @default.
- W2233729479 hasPublicationYear "2016" @default.
- W2233729479 type Work @default.
- W2233729479 sameAs 2233729479 @default.
- W2233729479 citedByCount "13" @default.
- W2233729479 countsByYear W22337294792016 @default.
- W2233729479 countsByYear W22337294792017 @default.
- W2233729479 countsByYear W22337294792018 @default.
- W2233729479 countsByYear W22337294792019 @default.
- W2233729479 countsByYear W22337294792022 @default.
- W2233729479 crossrefType "journal-article" @default.
- W2233729479 hasAuthorship W2233729479A5005390178 @default.
- W2233729479 hasAuthorship W2233729479A5006526481 @default.
- W2233729479 hasAuthorship W2233729479A5006920216 @default.
- W2233729479 hasAuthorship W2233729479A5008274065 @default.
- W2233729479 hasAuthorship W2233729479A5021374018 @default.
- W2233729479 hasAuthorship W2233729479A5024024464 @default.
- W2233729479 hasAuthorship W2233729479A5052390682 @default.
- W2233729479 hasAuthorship W2233729479A5057459026 @default.
- W2233729479 hasAuthorship W2233729479A5063263652 @default.
- W2233729479 hasAuthorship W2233729479A5078433399 @default.
- W2233729479 hasAuthorship W2233729479A5087627289 @default.
- W2233729479 hasBestOaLocation W22337294791 @default.
- W2233729479 hasConcept C104317684 @default.
- W2233729479 hasConcept C119056186 @default.
- W2233729479 hasConcept C121608353 @default.