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- W2233847540 abstract "Granule exocytosis in mast cells is controlled by membrane-membrane fusion proteins termed SNAREs (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors). SNARE protein mediate membrane fusion between synaptic vesicle and presynaptic membrane, resulting in mast cell fusion and releasing histamine, serotonin, and other inflammatory mediators. Blocking SNARE assembly process might exert the inhibition of mast cell fusion and releasing inflammatory mediators. In this study we examined the effects of SNARE inhibitor derived from plant extract on atopic dermatitis model using NC/Nga mice. Topical application of SNARE inhibitor reduced 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice in terms of several biological markers. Serum IgE level was reduced significantly after 4 weeks treatment. Mast cell number was also reduced significantly by inhibitor treatment. Number of scratching was reduced slightly but there was no significance. Our results raise the possibility that SNARE folding inhibitors from natural sources might used for treatment of atopic dermatitis." @default.
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- W2233847540 date "2010-02-01" @default.
- W2233847540 modified "2023-09-23" @default.
- W2233847540 title "Inhibition of atopic dermatitis by topical application of SNARE complex inhibitor in NC/Nga mice" @default.
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