FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233854610> ?p ?o ?g. }

• W2233854610 abstract "In many individuals, drug abuse is intimately linked with HIV-1 infection. In addition to being associated with one-third of all HIV-1 infections in the United States, drug abuse also plays a role in disease progression and severity in HIV-1-infected patients, including adverse effects on the central nervous system (CNS). Specific systems within the brain are known to be damaged in HIV-1-infected individuals and this damage is similar to that observed in drug abuse. Even in the era of anti-retroviral therapy (ART), CNS pathogenesis occurs with HIV-1 infection, with a broad range of cognitive impairment observed, collectively referred to as HIV-1-associated neurocognitive disorders (HAND). A number of HIV-1 proteins (Tat, gp120, Nef, Vpr) have been implicated in the etiology of pathogenesis and disease as a result of the biologic activity of the extracellular form of each of the proteins in a number of tissues, including the CNS, even in ART-suppressed patients. In this review, we have made Tat the center of attention for a number of reasons. First, it has been shown to be synthesized and secreted by HIV-1-infected cells in the CNS, despite the most effective suppression therapies available to date. Second, Tat has been shown to alter the functions of several host factors, disrupting the molecular and biochemical balance of numerous pathways contributing to cellular toxicity, dysfunction, and death. In addition, the advantages and disadvantages of ART suppression with regard to controlling the genesis and progression of neurocognitive impairment are currently under debate in the field and are yet to be fully determined. In this review, we discuss the individual and concerted contributions of HIV-1 Tat, drug abuse, and ART with respect to damage in the CNS, and how these factors contribute to the development of HAND in HIV-1-infected patients." @default.
• W2233854610 created "2016-06-24" @default.
• W2233854610 creator A5022311253 @default.
• W2233854610 creator A5034657105 @default.
• W2233854610 creator A5051546937 @default.
• W2233854610 creator A5072341058 @default.
• W2233854610 creator A5073048088 @default.
• W2233854610 date "2016-01-11" @default.
• W2233854610 modified "2023-10-18" @default.
• W2233854610 title "Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease" @default.
• W2233854610 cites W109222942 @default.
• W2233854610 cites W1520416168 @default.
• W2233854610 cites W1524845305 @default.
• W2233854610 cites W1544120675 @default.
• W2233854610 cites W1574896709 @default.
• W2233854610 cites W1588609678 @default.
• W2233854610 cites W1594197304 @default.
• W2233854610 cites W1600863966 @default.
• W2233854610 cites W1604636487 @default.
• W2233854610 cites W1727897997 @default.
• W2233854610 cites W1789490659 @default.
• W2233854610 cites W1877518964 @default.
• W2233854610 cites W1921194442 @default.
• W2233854610 cites W1926895509 @default.
• W2233854610 cites W1966389947 @default.
• W2233854610 cites W1968277627 @default.
• W2233854610 cites W1969902780 @default.
• W2233854610 cites W1971240525 @default.
• W2233854610 cites W1971575638 @default.
• W2233854610 cites W1971592398 @default.
• W2233854610 cites W1974747011 @default.
• W2233854610 cites W1975098452 @default.
• W2233854610 cites W1975974316 @default.
• W2233854610 cites W1976308450 @default.
• W2233854610 cites W1977677421 @default.
• W2233854610 cites W1978917197 @default.
• W2233854610 cites W1980280932 @default.
• W2233854610 cites W1981473511 @default.
• W2233854610 cites W1982069473 @default.
• W2233854610 cites W1983737585 @default.
• W2233854610 cites W1989155282 @default.
• W2233854610 cites W1989291725 @default.
• W2233854610 cites W1992364885 @default.
• W2233854610 cites W1992883702 @default.
• W2233854610 cites W1993264471 @default.
• W2233854610 cites W1993368983 @default.
• W2233854610 cites W1994556577 @default.
• W2233854610 cites W1995552285 @default.
• W2233854610 cites W1996476108 @default.
• W2233854610 cites W1997001890 @default.
• W2233854610 cites W1998529637 @default.
• W2233854610 cites W2003088831 @default.
• W2233854610 cites W2005358178 @default.
• W2233854610 cites W2008998239 @default.
• W2233854610 cites W2009905886 @default.
• W2233854610 cites W2010804532 @default.
• W2233854610 cites W2010875458 @default.
• W2233854610 cites W2014626304 @default.
• W2233854610 cites W2014964914 @default.
• W2233854610 cites W2015266566 @default.
• W2233854610 cites W2015829020 @default.
• W2233854610 cites W2017576536 @default.
• W2233854610 cites W2018393302 @default.
• W2233854610 cites W2025821801 @default.
• W2233854610 cites W2026141666 @default.
• W2233854610 cites W2026814484 @default.
• W2233854610 cites W2027905421 @default.
• W2233854610 cites W2029722878 @default.
• W2233854610 cites W2029843028 @default.
• W2233854610 cites W2030364709 @default.
• W2233854610 cites W2030657267 @default.
• W2233854610 cites W2032495224 @default.
• W2233854610 cites W2033410011 @default.
• W2233854610 cites W2036070626 @default.
• W2233854610 cites W2036335274 @default.
• W2233854610 cites W2037400076 @default.
• W2233854610 cites W2038016863 @default.
• W2233854610 cites W2038202750 @default.
• W2233854610 cites W2040170012 @default.
• W2233854610 cites W2043911219 @default.
• W2233854610 cites W2045275950 @default.
• W2233854610 cites W2045487496 @default.
• W2233854610 cites W2046468113 @default.
• W2233854610 cites W2046844745 @default.
• W2233854610 cites W2047838688 @default.
• W2233854610 cites W2047963679 @default.
• W2233854610 cites W2048757763 @default.
• W2233854610 cites W2049016894 @default.
• W2233854610 cites W2050067173 @default.
• W2233854610 cites W2051133054 @default.
• W2233854610 cites W2051444050 @default.
• W2233854610 cites W2052900571 @default.
• W2233854610 cites W2052919320 @default.
• W2233854610 cites W2055579254 @default.
• W2233854610 cites W2055765455 @default.
• W2233854610 cites W2055783050 @default.
• W2233854610 cites W2057261851 @default.
• W2233854610 cites W2060852391 @default.
• W2233854610 cites W2062012741 @default.
• W2233854610 cites W2063955495 @default.

• next