Matches in SemOpenAlex for { <https://semopenalex.org/work/W2233927272> ?p ?o ?g. }
- W2233927272 endingPage "141" @default.
- W2233927272 startingPage "137" @default.
- W2233927272 abstract "Mitochondria were isolated from rat adult liver, foetal liver, kidney cortex, heart, skeletal muscle and interscapular brown adipose tissue. DL-2-Bromopalmitoyl-CoA inhibited the overt form of carnitine palmitoyltransferase (CPT1) in heart, skeletal muscle and brown adipose tissue, with an IC50 value (concentration giving 50% inhibition) of 1.3-1.6 microM. By contrast, the IC50 value for inhibition of the kidney or adult liver enzyme was 0.08-0.1 microM. CPT1 in near-term foetal liver differed from that in adult liver in that the IC50 for inhibition by 2-bromopalmitoyl-CoA was 0.57 microM. It is suggested that there may be tissue-specific forms of the catalytic entity of CPT1 and that foetal liver may contain a mixture of adult liver- and muscle-type enzymes. In rats made hypothyroid by administration of propylthiouracil and an iodine-deficient diet, hepatic CPT1 activity was decreased by 83%. However, CPT1 activity in extrahepatic tissues showed no adaptive decrease in hypothyroidism." @default.
- W2233927272 created "2016-06-24" @default.
- W2233927272 creator A5002321857 @default.
- W2233927272 creator A5007926794 @default.
- W2233927272 date "1986-05-15" @default.
- W2233927272 modified "2023-09-27" @default.
- W2233927272 title "Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by dl-2-bromopalmitoyl-CoA and effect of hypothyroidism" @default.
- W2233927272 cites W102735503 @default.
- W2233927272 cites W145040958 @default.
- W2233927272 cites W1495212988 @default.
- W2233927272 cites W1522205670 @default.
- W2233927272 cites W1524786058 @default.
- W2233927272 cites W1548300567 @default.
- W2233927272 cites W1577348758 @default.
- W2233927272 cites W1579331744 @default.
- W2233927272 cites W1587545793 @default.
- W2233927272 cites W1775749144 @default.
- W2233927272 cites W1803441975 @default.
- W2233927272 cites W1837334890 @default.
- W2233927272 cites W1896686934 @default.
- W2233927272 cites W1966831974 @default.
- W2233927272 cites W1979950401 @default.
- W2233927272 cites W1981239667 @default.
- W2233927272 cites W1996780193 @default.
- W2233927272 cites W1997158815 @default.
- W2233927272 cites W1999134728 @default.
- W2233927272 cites W2000776928 @default.
- W2233927272 cites W2011458776 @default.
- W2233927272 cites W2016257988 @default.
- W2233927272 cites W2038342473 @default.
- W2233927272 cites W2084258827 @default.
- W2233927272 cites W2085129572 @default.
- W2233927272 cites W2090196900 @default.
- W2233927272 cites W2091598724 @default.
- W2233927272 cites W2115941718 @default.
- W2233927272 cites W2214862998 @default.
- W2233927272 cites W2228185931 @default.
- W2233927272 cites W2256351467 @default.
- W2233927272 cites W2338334856 @default.
- W2233927272 cites W2343629425 @default.
- W2233927272 cites W2344717653 @default.
- W2233927272 cites W2395642781 @default.
- W2233927272 cites W2404646134 @default.
- W2233927272 cites W43695440 @default.
- W2233927272 cites W7120801 @default.
- W2233927272 doi "https://doi.org/10.1042/bj2360137" @default.
- W2233927272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1146797" @default.
- W2233927272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3790066" @default.
- W2233927272 hasPublicationYear "1986" @default.
- W2233927272 type Work @default.
- W2233927272 sameAs 2233927272 @default.
- W2233927272 citedByCount "49" @default.
- W2233927272 countsByYear W22339272722013 @default.
- W2233927272 countsByYear W22339272722014 @default.
- W2233927272 countsByYear W22339272722017 @default.
- W2233927272 countsByYear W22339272722019 @default.
- W2233927272 countsByYear W22339272722020 @default.
- W2233927272 countsByYear W22339272722022 @default.
- W2233927272 crossrefType "journal-article" @default.
- W2233927272 hasAuthorship W2233927272A5002321857 @default.
- W2233927272 hasAuthorship W2233927272A5007926794 @default.
- W2233927272 hasBestOaLocation W22339272722 @default.
- W2233927272 hasConcept C126322002 @default.
- W2233927272 hasConcept C134018914 @default.
- W2233927272 hasConcept C171089720 @default.
- W2233927272 hasConcept C185592680 @default.
- W2233927272 hasConcept C2775960720 @default.
- W2233927272 hasConcept C2776423169 @default.
- W2233927272 hasConcept C2776614356 @default.
- W2233927272 hasConcept C2778435403 @default.
- W2233927272 hasConcept C2779959927 @default.
- W2233927272 hasConcept C2780091579 @default.
- W2233927272 hasConcept C2780642333 @default.
- W2233927272 hasConcept C526584372 @default.
- W2233927272 hasConcept C62231903 @default.
- W2233927272 hasConcept C71924100 @default.
- W2233927272 hasConcept C82714985 @default.
- W2233927272 hasConcept C86803240 @default.
- W2233927272 hasConceptScore W2233927272C126322002 @default.
- W2233927272 hasConceptScore W2233927272C134018914 @default.
- W2233927272 hasConceptScore W2233927272C171089720 @default.
- W2233927272 hasConceptScore W2233927272C185592680 @default.
- W2233927272 hasConceptScore W2233927272C2775960720 @default.
- W2233927272 hasConceptScore W2233927272C2776423169 @default.
- W2233927272 hasConceptScore W2233927272C2776614356 @default.
- W2233927272 hasConceptScore W2233927272C2778435403 @default.
- W2233927272 hasConceptScore W2233927272C2779959927 @default.
- W2233927272 hasConceptScore W2233927272C2780091579 @default.
- W2233927272 hasConceptScore W2233927272C2780642333 @default.
- W2233927272 hasConceptScore W2233927272C526584372 @default.
- W2233927272 hasConceptScore W2233927272C62231903 @default.
- W2233927272 hasConceptScore W2233927272C71924100 @default.
- W2233927272 hasConceptScore W2233927272C82714985 @default.
- W2233927272 hasConceptScore W2233927272C86803240 @default.
- W2233927272 hasIssue "1" @default.
- W2233927272 hasLocation W22339272721 @default.
- W2233927272 hasLocation W22339272722 @default.
- W2233927272 hasLocation W22339272723 @default.