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• W2233999730 endingPage "10" @default.
• W2233999730 startingPage "10" @default.
• W2233999730 abstract "Glutamate is a neurotransmitter used at both the peripheral and central terminals of nociceptive primary sensory neurons, yet little is known concerning regulation of glutamate metabolism during peripheral inflammation. Glutaminase (GLS) is an enzyme of the glutamate-glutamine cycle that converts glutamine into glutamate for neurotransmission and is implicated in producing elevated levels of glutamate in central and peripheral terminals. A potential mechanism for increased levels of glutamate is an elevation in GLS expression. We assessed GLS expression after unilateral hind paw inflammation by measuring GLS immunoreactivity (ir) with quantitative image analysis of L4 dorsal root ganglion (DRG) neurons after one, two, four, and eight days of adjuvant-induced arthritis (AIA) compared to saline injected controls. No significant elevation in GLS-ir occurred in the DRG ipsilateral to the inflamed hind paw after one or two days of AIA. After four days AIA, GLS-ir was elevated significantly in all sizes of DRG neurons. After eight days AIA, GLS-ir remained elevated in small (<400 µm2), presumably nociceptive neurons. Western blot analysis of the L4 DRG at day four AIA confirmed the elevated GLS-ir. The present study indicates that GLS expression is increased in the chronic stage of inflammation and may be a target for chronic pain therapy." @default.
• W2233999730 created "2016-06-24" @default.
• W2233999730 creator A5012649679 @default.
• W2233999730 creator A5018997536 @default.
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• W2233999730 creator A5048323018 @default.
• W2233999730 date "2016-01-13" @default.
• W2233999730 modified "2023-10-14" @default.
• W2233999730 title "Glutaminase Increases in Rat Dorsal Root Ganglion Neurons after Unilateral Adjuvant-Induced Hind Paw Inflammation" @default.
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• W2233999730 doi "https://doi.org/10.3390/biom6010010" @default.
• W2233999730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4808804" @default.
• W2233999730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26771651" @default.
• W2233999730 hasPublicationYear "2016" @default.
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