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• W2234178172 abstract "During pregnancy, physiologic changes occur in the woman's body, which potentially can alter the way in which drugs are handled. A few pharmacokinetic (PK), pharmacodynamic, or clinical trials are conducted during pregnancy because of concerns for fetal safety. The risk most commonly considered is the fetal risk of teratogenesis or drug-induced malformation. Maternal physiologic changes occur during gestation to accommodate fetal growth and development. This altered maternal physiology has the potential to affect the PK of drugs. These changes may increase drug distribution volume, decrease drug binding to plasma proteins, alter peak drug concentration and time to peak drug concentration, and cause changes in hepatic and/or renal drug clearance. Disregard of these changes in maternal physiology may affect drug efficacy impacting maternal disease and potentially overall pregnancy outcome. The expanded age of reproduction coupled with pregnancy occurring later in life effectively increases the number of women who require drug therapy for diseases present before pregnancy and who need to continue therapy during pregnancy. Adequate and well-studied therapies are needed to optimally treat pregnant women with underlying diseases." @default.
• W2234178172 created "2016-06-24" @default.
• W2234178172 creator A5071842770 @default.
• W2234178172 date "2004-01-01" @default.
• W2234178172 modified "2023-09-27" @default.
• W2234178172 title "Consideration for the Use of Therapeutic Drugs During Pregnancy and the Perinatal Period" @default.
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• W2234178172 doi "https://doi.org/10.1016/b978-012440905-7/50351-0" @default.
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