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• W2234283722 endingPage "553" @default.
• W2234283722 startingPage "543" @default.
• W2234283722 abstract "We recently reported that provocative motion (rotation in a home cage) causes hypothermic responses in rats, similar to the hypothermic responses associated with motion sickness in humans. Many stimuli inducing emesis in species with an emetic reflex also provoke hypothermia in the rat, therefore we hypothesized that a fall in body temperature may reflect a “nausea-like” state in these animals. As rats do not possess an emetic reflex, we employed a pharmacological approach to test this hypothesis. In humans, motion- and chemically-induced nausea have differential sensitivity to anti-emetics. We thus tested whether the hypothermia induced in rats by provocative motion (rotation at 0.7 Hz) and by the emetic LiCl (63 mg/kg i.p.) have a similar differential pharmacological sensitivity. Both provocations caused a comparable robust fall in core body temperature (−1.9 ± 0.3°C and −2.0 ± 0.2°C for chemical and motion provocations, respectively). LiCl−induced hypothermia was completely prevented by ondansetron (2mg/kg, i.p., a 5-HT3 receptor antagonist that reduces cancer chemotherapy-induced nausea and vomiting), but was insensitive to promethazine (10 mg/kg, i.p., a predominantly histamine-H1 and muscarinic receptor antagonist that is commonly used to treat motion sickness). Conversely, motion-induced hypothermia was unaffected by ondansetron but promethazine reduced the rate of temperature decline from 0.20 ± 0.02 to 0.11 ± 0.03°C/min (P < 0.05) with a trend to decrease the magnitude. We conclude that this differential pharmacological sensitivity of the hypothermic responses of vestibular vs. chemical etiology in rats mirrors the observations in other pre-clinical models and humans, and thus supports the idea that a “nausea-like” state in rodents is associated with disturbances in thermoregulation." @default.
• W2234283722 created "2016-06-24" @default.
• W2234283722 creator A5011855649 @default.
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• W2234283722 creator A5057743293 @default.
• W2234283722 creator A5081947723 @default.
• W2234283722 date "2015-10-02" @default.
• W2234283722 modified "2023-09-27" @default.
• W2234283722 title "Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats" @default.
• W2234283722 cites W103292242 @default.
• W2234283722 cites W127429958 @default.
• W2234283722 cites W141997249 @default.
• W2234283722 cites W150253810 @default.
• W2234283722 cites W1518008595 @default.
• W2234283722 cites W1659852657 @default.
• W2234283722 cites W1820781509 @default.
• W2234283722 cites W1863880589 @default.
• W2234283722 cites W1915454019 @default.
• W2234283722 cites W1966681272 @default.
• W2234283722 cites W1972174558 @default.
• W2234283722 cites W1979972995 @default.
• W2234283722 cites W1982753058 @default.
• W2234283722 cites W1984149491 @default.
• W2234283722 cites W1987248916 @default.
• W2234283722 cites W1988300555 @default.
• W2234283722 cites W1989062105 @default.
• W2234283722 cites W1990883824 @default.
• W2234283722 cites W1993238579 @default.
• W2234283722 cites W1993738925 @default.
• W2234283722 cites W1995001227 @default.
• W2234283722 cites W1997029713 @default.
• W2234283722 cites W2001586299 @default.
• W2234283722 cites W2001861109 @default.
• W2234283722 cites W2009725907 @default.
• W2234283722 cites W2009934685 @default.
• W2234283722 cites W2014357799 @default.
• W2234283722 cites W2016833985 @default.
• W2234283722 cites W2021144796 @default.
• W2234283722 cites W2025352373 @default.
• W2234283722 cites W2026070129 @default.
• W2234283722 cites W2029079477 @default.
• W2234283722 cites W2029698088 @default.
• W2234283722 cites W2033739190 @default.
• W2234283722 cites W2035876098 @default.
• W2234283722 cites W2036086978 @default.
• W2234283722 cites W2036863594 @default.
• W2234283722 cites W2037728819 @default.
• W2234283722 cites W2039449693 @default.
• W2234283722 cites W2041699770 @default.
• W2234283722 cites W2043085921 @default.
• W2234283722 cites W2046581354 @default.
• W2234283722 cites W2049075621 @default.
• W2234283722 cites W2049364883 @default.
• W2234283722 cites W2053188801 @default.
• W2234283722 cites W2057992483 @default.
• W2234283722 cites W2060885716 @default.
• W2234283722 cites W2069598518 @default.
• W2234283722 cites W2070262579 @default.
• W2234283722 cites W2071923881 @default.
• W2234283722 cites W2072350144 @default.
• W2234283722 cites W2075469552 @default.
• W2234283722 cites W2076994104 @default.
• W2234283722 cites W2080989089 @default.
• W2234283722 cites W2083077785 @default.
• W2234283722 cites W2083557005 @default.
• W2234283722 cites W2087717777 @default.
• W2234283722 cites W2088869289 @default.
• W2234283722 cites W2090334512 @default.
• W2234283722 cites W2091608595 @default.
• W2234283722 cites W2095467009 @default.
• W2234283722 cites W2102216249 @default.
• W2234283722 cites W2103859861 @default.
• W2234283722 cites W2105155111 @default.
• W2234283722 cites W2116682901 @default.
• W2234283722 cites W2131155720 @default.
• W2234283722 cites W2136401727 @default.
• W2234283722 cites W2147691780 @default.
• W2234283722 cites W2147702220 @default.
• W2234283722 cites W2157297366 @default.
• W2234283722 cites W2168051414 @default.
• W2234283722 cites W2238630659 @default.
• W2234283722 cites W225248372 @default.
• W2234283722 cites W2290649233 @default.
• W2234283722 cites W2461817482 @default.
• W2234283722 cites W4241718101 @default.
• W2234283722 cites W4250819259 @default.
• W2234283722 cites W4251931597 @default.
• W2234283722 cites W4253302301 @default.
• W2234283722 doi "https://doi.org/10.1080/23328940.2015.1071700" @default.
• W2234283722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4843929" @default.
• W2234283722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27227074" @default.
• W2234283722 hasPublicationYear "2015" @default.
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