FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2234334930> ?p ?o ?g. }

• W2234334930 endingPage "3246" @default.
• W2234334930 startingPage "3233" @default.
• W2234334930 abstract "Hua, Shao-Ying, Dorota A. Raciborska, William S. Trimble, and Milton P. Charlton. Different VAMP/synaptobrevin complexes for spontaneous and evoked transmitter release at the crayfish neuromuscular junction. J. Neurophysiol. 80: 3233–3246, 1998. Although vesicle-associated membrane protein (VAMP/synaptobrevin) is essential for evoked neurotransmitter release, its role in spontaneous transmitter release remains uncertain. For instance, many studies show that tetanus toxin (TeNT), which cleaves VAMP, blocks evoked transmitter release but leaves some spontaneous transmitter release. We used recombinant tetanus and botulinum neurotoxin catalytic light chains (TeNT-LC, BoNT/B-LC, and BoNT/D-LC) to examine the role of VAMP in spontaneous transmitter release at neuromuscular junctions (nmj) of crayfish. Injection of TeNT-LC into presynaptic axons removed most of the VAMP immunoreactivity and blocked evoked transmitter release without affecting nerve action potentials or Ca 2+ influx. The frequency of spontaneous transmitter release was little affected by the TeNT-LC when the evoked transmitter release had been blocked by >95%. The spontaneous transmitter release left after TeNT-LC treatment was insensitive to increases in intracellular Ca 2+ . BoNT/B-LC, which cleaves VAMP at the same site as TeNT-LC but uses a different binding site, also blocked evoked release but had minimal effect on spontaneous release. However, BoNT/D-LC, which cleaves VAMP at a different site from the other two toxins but binds to the same position on VAMP as TeNT, blocked both evoked and spontaneous transmitter release at similar rates. The data indicate that different VAMP complexes are employed for evoked and spontaneous transmitter release; the VAMP used in spontaneous release is not readily cleaved by TeNT or BoNT/B. Because the exocytosis that occurs after the action of TeNT cannot be increased by increased intracellular Ca 2+ , the final steps in neurotransmitter release are Ca 2+ independent." @default.
• W2234334930 created "2016-06-24" @default.
• W2234334930 creator A5007523838 @default.
• W2234334930 creator A5013848456 @default.
• W2234334930 creator A5077560534 @default.
• W2234334930 creator A5079112292 @default.
• W2234334930 date "1998-12-01" @default.
• W2234334930 modified "2023-09-27" @default.
• W2234334930 title "Different VAMP/Synaptobrevin Complexes for Spontaneous and Evoked Transmitter Release at the Crayfish Neuromuscular Junction" @default.
• W2234334930 cites W125581701 @default.
• W2234334930 cites W1498501785 @default.
• W2234334930 cites W1509564548 @default.
• W2234334930 cites W1529141138 @default.
• W2234334930 cites W1530469978 @default.
• W2234334930 cites W1535329260 @default.
• W2234334930 cites W1555714096 @default.
• W2234334930 cites W1602626976 @default.
• W2234334930 cites W1607967639 @default.
• W2234334930 cites W1649931880 @default.
• W2234334930 cites W1793584849 @default.
• W2234334930 cites W1883653169 @default.
• W2234334930 cites W1965058807 @default.
• W2234334930 cites W1973130739 @default.
• W2234334930 cites W1977443461 @default.
• W2234334930 cites W1977478068 @default.
• W2234334930 cites W1981564602 @default.
• W2234334930 cites W1987460091 @default.
• W2234334930 cites W1990005793 @default.
• W2234334930 cites W1990482183 @default.
• W2234334930 cites W1997507057 @default.
• W2234334930 cites W1997778299 @default.
• W2234334930 cites W2002095327 @default.
• W2234334930 cites W2011494098 @default.
• W2234334930 cites W2017051139 @default.
• W2234334930 cites W2020294780 @default.
• W2234334930 cites W2020574287 @default.
• W2234334930 cites W2033500343 @default.
• W2234334930 cites W2036660516 @default.
• W2234334930 cites W2037817334 @default.
• W2234334930 cites W2040167839 @default.
• W2234334930 cites W2040641684 @default.
• W2234334930 cites W2044902565 @default.
• W2234334930 cites W2048019766 @default.
• W2234334930 cites W2048035298 @default.
• W2234334930 cites W2051360960 @default.
• W2234334930 cites W2055947351 @default.
• W2234334930 cites W2059384592 @default.
• W2234334930 cites W2070083683 @default.
• W2234334930 cites W2073672089 @default.
• W2234334930 cites W2075449190 @default.
• W2234334930 cites W2081575009 @default.
• W2234334930 cites W2085445776 @default.
• W2234334930 cites W2088213270 @default.
• W2234334930 cites W2088244069 @default.
• W2234334930 cites W2089333920 @default.
• W2234334930 cites W2096925397 @default.
• W2234334930 cites W2097699434 @default.
• W2234334930 cites W2104801664 @default.
• W2234334930 cites W2117358231 @default.
• W2234334930 cites W2133411939 @default.
• W2234334930 cites W2143422184 @default.
• W2234334930 cites W2143452465 @default.
• W2234334930 cites W2149260921 @default.
• W2234334930 cites W2159942581 @default.
• W2234334930 cites W2161485116 @default.
• W2234334930 cites W2187757573 @default.
• W2234334930 cites W2234822783 @default.
• W2234334930 cites W3021526609 @default.
• W2234334930 cites W306153470 @default.
• W2234334930 cites W4300569677 @default.
• W2234334930 cites W2042759439 @default.
• W2234334930 doi "https://doi.org/10.1152/jn.1998.80.6.3233" @default.
• W2234334930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9862918" @default.
• W2234334930 hasPublicationYear "1998" @default.
• W2234334930 type Work @default.
• W2234334930 sameAs 2234334930 @default.
• W2234334930 citedByCount "64" @default.
• W2234334930 countsByYear W22343349302012 @default.
• W2234334930 countsByYear W22343349302014 @default.
• W2234334930 countsByYear W22343349302015 @default.
• W2234334930 countsByYear W22343349302016 @default.
• W2234334930 countsByYear W22343349302017 @default.
• W2234334930 countsByYear W22343349302019 @default.
• W2234334930 countsByYear W22343349302021 @default.
• W2234334930 countsByYear W22343349302022 @default.
• W2234334930 crossrefType "journal-article" @default.
• W2234334930 hasAuthorship W2234334930A5007523838 @default.
• W2234334930 hasAuthorship W2234334930A5013848456 @default.
• W2234334930 hasAuthorship W2234334930A5077560534 @default.
• W2234334930 hasAuthorship W2234334930A5079112292 @default.
• W2234334930 hasConcept C12554922 @default.
• W2234334930 hasConcept C130316041 @default.
• W2234334930 hasConcept C148785051 @default.
• W2234334930 hasConcept C169760540 @default.
• W2234334930 hasConcept C185592680 @default.
• W2234334930 hasConcept C2776219046 @default.
• W2234334930 hasConcept C2777029164 @default.
• W2234334930 hasConcept C2777240379 @default.

• next