Matches in SemOpenAlex for { <https://semopenalex.org/work/W2234604554> ?p ?o ?g. }
- W2234604554 abstract "Abstract Background Amelogenin is an extracellular matrix protein well known for its role in the organization and mineralization of enamel. Clinically, it is used for periodontal regeneration and, due to its finding also in predentin and intercellular spaces of dental pulp cells, it has recently been suggested for pulp capping procedures. The aim of this study was to analyse in vitro the effect of the recombinant human full-length amelogenin on the growth and differentiation of human dental pulp stem cells (hDPSCs). Methods Human DPSCs were treated with a supplement of amelogenin at a concentration of 10 ng/ml, 100 ng/ml and 1000 ng/ml. The groups were compared to the unstimulated control in terms of cell morphology and proliferation, mineralization and gene expression for ALP (alkaline phosphatase), DMP1 (dentin matrix protein-1) and DSPP (dentin sialophosphoprotein). Results Amelogenin affects hDPSCs differently than PDL (periodontal ligament) cells and other cell lines. The proliferation rate at two weeks is significantly reduced in presence of the highest concentration of amelogenin as compared to the unstimulated control. hDPSCs treated with low concentrations present a downregulation of DMP1 and DSPP, which is significant for DSPP (p = 0.011), but not for DMP1 (p = 0.395). Conclusions These finding suggest that the role of full-length amelogenin is not restricted to participation in tooth structure. It influences the differentiation of hDPSC according to various concentrations and this might impair the clinical results of pulp capping." @default.
- W2234604554 created "2016-06-24" @default.
- W2234604554 creator A5008851151 @default.
- W2234604554 creator A5009401472 @default.
- W2234604554 creator A5012550002 @default.
- W2234604554 creator A5016099826 @default.
- W2234604554 creator A5074577116 @default.
- W2234604554 creator A5078381053 @default.
- W2234604554 date "2016-01-13" @default.
- W2234604554 modified "2023-10-02" @default.
- W2234604554 title "Full-length amelogenin influences the differentiation of human dental pulp stem cells" @default.
- W2234604554 cites W148120292 @default.
- W2234604554 cites W1488249169 @default.
- W2234604554 cites W1521262132 @default.
- W2234604554 cites W1898256626 @default.
- W2234604554 cites W1928208953 @default.
- W2234604554 cites W1964436880 @default.
- W2234604554 cites W1966600092 @default.
- W2234604554 cites W1967712997 @default.
- W2234604554 cites W1977291770 @default.
- W2234604554 cites W1980002104 @default.
- W2234604554 cites W1981726684 @default.
- W2234604554 cites W1986756668 @default.
- W2234604554 cites W1998317358 @default.
- W2234604554 cites W2006268937 @default.
- W2234604554 cites W2006894650 @default.
- W2234604554 cites W2012007342 @default.
- W2234604554 cites W2019916074 @default.
- W2234604554 cites W2027012204 @default.
- W2234604554 cites W2034381565 @default.
- W2234604554 cites W2039554837 @default.
- W2234604554 cites W2046529617 @default.
- W2234604554 cites W2050446363 @default.
- W2234604554 cites W2056983170 @default.
- W2234604554 cites W2065445399 @default.
- W2234604554 cites W2073745251 @default.
- W2234604554 cites W2080698361 @default.
- W2234604554 cites W2084120353 @default.
- W2234604554 cites W2085190985 @default.
- W2234604554 cites W2086500484 @default.
- W2234604554 cites W2090205800 @default.
- W2234604554 cites W2094184848 @default.
- W2234604554 cites W2094935991 @default.
- W2234604554 cites W2111553051 @default.
- W2234604554 cites W2113049320 @default.
- W2234604554 cites W2115456803 @default.
- W2234604554 cites W2120294300 @default.
- W2234604554 cites W2129146352 @default.
- W2234604554 cites W2160215427 @default.
- W2234604554 cites W2169492617 @default.
- W2234604554 cites W2297551112 @default.
- W2234604554 cites W43830513 @default.
- W2234604554 doi "https://doi.org/10.1186/s13287-015-0269-9" @default.
- W2234604554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4712507" @default.
- W2234604554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26762641" @default.
- W2234604554 hasPublicationYear "2016" @default.
- W2234604554 type Work @default.
- W2234604554 sameAs 2234604554 @default.
- W2234604554 citedByCount "14" @default.
- W2234604554 countsByYear W22346045542016 @default.
- W2234604554 countsByYear W22346045542018 @default.
- W2234604554 countsByYear W22346045542019 @default.
- W2234604554 countsByYear W22346045542020 @default.
- W2234604554 countsByYear W22346045542021 @default.
- W2234604554 countsByYear W22346045542022 @default.
- W2234604554 countsByYear W22346045542023 @default.
- W2234604554 crossrefType "journal-article" @default.
- W2234604554 hasAuthorship W2234604554A5008851151 @default.
- W2234604554 hasAuthorship W2234604554A5009401472 @default.
- W2234604554 hasAuthorship W2234604554A5012550002 @default.
- W2234604554 hasAuthorship W2234604554A5016099826 @default.
- W2234604554 hasAuthorship W2234604554A5074577116 @default.
- W2234604554 hasAuthorship W2234604554A5078381053 @default.
- W2234604554 hasBestOaLocation W22346045541 @default.
- W2234604554 hasConcept C104317684 @default.
- W2234604554 hasConcept C106434640 @default.
- W2234604554 hasConcept C156887251 @default.
- W2234604554 hasConcept C171056886 @default.
- W2234604554 hasConcept C185592680 @default.
- W2234604554 hasConcept C188442228 @default.
- W2234604554 hasConcept C189165786 @default.
- W2234604554 hasConcept C199343813 @default.
- W2234604554 hasConcept C2520015 @default.
- W2234604554 hasConcept C2777267240 @default.
- W2234604554 hasConcept C2777400515 @default.
- W2234604554 hasConcept C2778185831 @default.
- W2234604554 hasConcept C2779203663 @default.
- W2234604554 hasConcept C2779263046 @default.
- W2234604554 hasConcept C28328180 @default.
- W2234604554 hasConcept C28406088 @default.
- W2234604554 hasConcept C41868710 @default.
- W2234604554 hasConcept C55493867 @default.
- W2234604554 hasConcept C68434959 @default.
- W2234604554 hasConcept C71924100 @default.
- W2234604554 hasConcept C86803240 @default.
- W2234604554 hasConcept C95444343 @default.
- W2234604554 hasConceptScore W2234604554C104317684 @default.
- W2234604554 hasConceptScore W2234604554C106434640 @default.
- W2234604554 hasConceptScore W2234604554C156887251 @default.
- W2234604554 hasConceptScore W2234604554C171056886 @default.