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- W2234689348 abstract "AbstractTwo separate HPLC methods were developed for the In-vitro dissolution of Alendronate sodium and Vitamin D3 tablets using Ultra-violet and Refractive index detection. Dissolution method for the estimation of Alendronate sodium (Method-I) in the fixed dose combination uses High Performance Liquid Chromatogaphy (HPLC) with Refractive Index detector (RID) whereas dissolution method for Vitamin D3 (Method-II) uses HPLC with Ultraviolet detector. Method-I uses Hamilton PRP-X500 (150 x 4.6) mm, 7 µ column with 0.01 % Trifluoro acetic acid in water, pH adjusted to 2.5 as mobile phase at a flow rate of 1.5 mL min−1 with Refractive detector sensitivity of 256. Method-II uses Zorbax SB CN (150 x 4.6) mm, 5 µ column with a mixture of water, methanol and acetonitrile in the ratio of 20:72:8 v/v/v as mobile phase at a flow rate of 1.2 mL min−1 with Ultraviolet (UV) detector wavelength of 266 nm. The method was validated for specificity, linearity, precision, accuracy and robustness as per International Conferen..." @default.
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- W2234689348 date "2015-07-04" @default.
- W2234689348 modified "2023-09-24" @default.
- W2234689348 title "In vitroDissolution Method for Alendronate Sodium and Vitamin D3 Tablets Using HPLC with Combination of Refractive Index and Ultraviolet Detectors" @default.
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- W2234689348 doi "https://doi.org/10.1080/22297928.2015.1090331" @default.
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