FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2234721973> ?p ?o ?g. }

• W2234721973 endingPage "1166" @default.
• W2234721973 startingPage "1158" @default.
• W2234721973 abstract "Previous experimental studies of both cortical barrel and thalamic barreloid neuron responses in rodent somatosensory cortex have indicated an active role for barrel circuitry in processing thalamic signals. Previous modeling studies of the same system have suggested that a major function of the barrel circuit is to render the response magnitude of barrel neurons particularly sensitive to the temporal distribution of thalamic input. Specifically, thalamic inputs that are initially synchronous strongly engage recurrent excitatory connections in the barrel and generate a response that briefly withstands the strong damping effects of inhibitory circuitry. To test this experimentally, we recorded responses from 40 cortical barrel neurons and 63 thalamic barreloid neurons evoked by whisker deflections varying in velocity and amplitude. This stimulus evoked thalamic response profiles that varied in terms of both their magnitude and timing. The magnitude of the thalamic population response, measured as the average number of evoked spikes per stimulus, increased with both deflection velocity and amplitude. On the other hand, the degree of initial synchrony, measured from population peristimulus time histograms, was highly correlated with the velocity of whisker deflection, deflection amplitude having little or no effect on thalamic synchrony. Consistent with the predictions of the model, the cortical population response was determined largely by whisker velocity and was highly correlated with the degree of initial synchrony among thalamic neurons (R(2) = 0.91), as compared with the average number of evoked thalamic spikes (R(2) = 0.38). Individually, the response of nearly all cortical cells displayed a positive correlation with deflection velocity; this homogeneity is consistent with the dependence of the cortical response on local circuit interactions as proposed by the model. By contrast, the response of individual thalamic neurons varied widely. These findings validate the predictions of the modeling studies and, more importantly, demonstrate that the mechanism by which the cortex processes an afferent signal is inextricably linked with, and in fact determines, the saliency of neural codes embedded in the thalamic response." @default.
• W2234721973 created "2016-06-24" @default.
• W2234721973 creator A5006468035 @default.
• W2234721973 creator A5037475408 @default.
• W2234721973 creator A5058534161 @default.
• W2234721973 date "2000-03-01" @default.
• W2234721973 modified "2023-10-11" @default.
• W2234721973 title "Circuit Dynamics and Coding Strategies in Rodent Somatosensory Cortex" @default.
• W2234721973 cites W107367680 @default.
• W2234721973 cites W1561541164 @default.
• W2234721973 cites W1574713718 @default.
• W2234721973 cites W160899559 @default.
• W2234721973 cites W169126144 @default.
• W2234721973 cites W190519938 @default.
• W2234721973 cites W1968367673 @default.
• W2234721973 cites W1969769253 @default.
• W2234721973 cites W1974439800 @default.
• W2234721973 cites W1996706235 @default.
• W2234721973 cites W2017494775 @default.
• W2234721973 cites W2019232485 @default.
• W2234721973 cites W2020616445 @default.
• W2234721973 cites W2025761070 @default.
• W2234721973 cites W2040739363 @default.
• W2234721973 cites W2055160369 @default.
• W2234721973 cites W2058484439 @default.
• W2234721973 cites W2059438119 @default.
• W2234721973 cites W2060414257 @default.
• W2234721973 cites W2063621508 @default.
• W2234721973 cites W2072649601 @default.
• W2234721973 cites W2079948225 @default.
• W2234721973 cites W2100087394 @default.
• W2234721973 cites W2117731089 @default.
• W2234721973 cites W2140008816 @default.
• W2234721973 cites W2150627463 @default.
• W2234721973 cites W2161872000 @default.
• W2234721973 cites W2172513721 @default.
• W2234721973 cites W2186169542 @default.
• W2234721973 cites W2212340109 @default.
• W2234721973 cites W2256282866 @default.
• W2234721973 cites W2290046961 @default.
• W2234721973 cites W2359361761 @default.
• W2234721973 cites W2405027732 @default.
• W2234721973 cites W2411237684 @default.
• W2234721973 cites W2414607473 @default.
• W2234721973 doi "https://doi.org/10.1152/jn.2000.83.3.1158" @default.
• W2234721973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10712446" @default.
• W2234721973 hasPublicationYear "2000" @default.
• W2234721973 type Work @default.
• W2234721973 sameAs 2234721973 @default.
• W2234721973 citedByCount "222" @default.
• W2234721973 countsByYear W22347219732012 @default.
• W2234721973 countsByYear W22347219732013 @default.
• W2234721973 countsByYear W22347219732014 @default.
• W2234721973 countsByYear W22347219732015 @default.
• W2234721973 countsByYear W22347219732016 @default.
• W2234721973 countsByYear W22347219732017 @default.
• W2234721973 countsByYear W22347219732018 @default.
• W2234721973 countsByYear W22347219732019 @default.
• W2234721973 countsByYear W22347219732020 @default.
• W2234721973 countsByYear W22347219732021 @default.
• W2234721973 countsByYear W22347219732022 @default.
• W2234721973 countsByYear W22347219732023 @default.
• W2234721973 crossrefType "journal-article" @default.
• W2234721973 hasAuthorship W2234721973A5006468035 @default.
• W2234721973 hasAuthorship W2234721973A5037475408 @default.
• W2234721973 hasAuthorship W2234721973A5058534161 @default.
• W2234721973 hasConcept C112592302 @default.
• W2234721973 hasConcept C121332964 @default.
• W2234721973 hasConcept C15744967 @default.
• W2234721973 hasConcept C169760540 @default.
• W2234721973 hasConcept C17077164 @default.
• W2234721973 hasConcept C172497186 @default.
• W2234721973 hasConcept C2779246727 @default.
• W2234721973 hasConcept C2779918689 @default.
• W2234721973 hasConcept C2781347215 @default.
• W2234721973 hasConcept C2908647359 @default.
• W2234721973 hasConcept C542102704 @default.
• W2234721973 hasConcept C71924100 @default.
• W2234721973 hasConcept C94487597 @default.
• W2234721973 hasConcept C99454951 @default.
• W2234721973 hasConceptScore W2234721973C112592302 @default.
• W2234721973 hasConceptScore W2234721973C121332964 @default.
• W2234721973 hasConceptScore W2234721973C15744967 @default.
• W2234721973 hasConceptScore W2234721973C169760540 @default.
• W2234721973 hasConceptScore W2234721973C17077164 @default.
• W2234721973 hasConceptScore W2234721973C172497186 @default.
• W2234721973 hasConceptScore W2234721973C2779246727 @default.
• W2234721973 hasConceptScore W2234721973C2779918689 @default.
• W2234721973 hasConceptScore W2234721973C2781347215 @default.
• W2234721973 hasConceptScore W2234721973C2908647359 @default.
• W2234721973 hasConceptScore W2234721973C542102704 @default.
• W2234721973 hasConceptScore W2234721973C71924100 @default.
• W2234721973 hasConceptScore W2234721973C94487597 @default.
• W2234721973 hasConceptScore W2234721973C99454951 @default.
• W2234721973 hasIssue "3" @default.
• W2234721973 hasLocation W22347219731 @default.
• W2234721973 hasLocation W22347219732 @default.
• W2234721973 hasOpenAccess W2234721973 @default.

• next