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- W2234781105 abstract "Objectives The aim of this study was to investigate the diagnostic and predictive value of plasma brain natriuretic peptide (BNP) levels in detecting diastolic dysfunction in β-thalassemic patients in comparison with conventional and new Doppler echocardiography indices. Background β-Thalassemia major is a unique disease characterized by early diastolic dysfunction related exclusively to iron myocardial deposition. BNP is a sensitive biomarker for the detection of asymptomatic left ventricular (LV) dysfunction and has important diagnostic and prognostic implications. Materials and methods This study enrolled 25 b-thalassemic major patients with normal systolic function and 10 age-matched and sex-matched individuals. All participants were studied thoroughly by tissue Doppler echocardiography and blood samples were taken for determination of BNP, ferritin, total iron, and complete blood count. Patients were divided into two groups according to the E mitral/E mitral annulus ratio (E/E') at cutoff point 8. Results BNP levels were higher in thalassemic patients compared with the control group. BNP and serum ferritin levels showed a statistically significant increase in group I (E/E' >8) in comparison with group II (E/E' P = 0.003) in ruling out diastolic dysfunction (E/E' Conclusion BNP level is significantly increased in LV diastolic dysfunction and has a predictive value in detecting latent LV diastolic dysfunction in β-thalassemia major." @default.
- W2234781105 created "2016-06-24" @default.
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- W2234781105 date "2015-01-01" @default.
- W2234781105 modified "2023-09-27" @default.
- W2234781105 title "Plasma brain natriuretic peptide concentration in β-thalassemia patients" @default.
- W2234781105 cites W1490504688 @default.
- W2234781105 doi "https://doi.org/10.4103/1110-2098.173693" @default.
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