FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2234830428> ?p ?o ?g. }

• W2234830428 endingPage "1928" @default.
• W2234830428 startingPage "1921" @default.
• W2234830428 abstract "Despite major advances in the management of metastatic colorectal cancer (mCRC) with liver-only involvement, relapse rates are high and reliable prognostic markers are needed.To assess the prognostic impact of BRAF and RAS mutations in a large series of liver-resected patients, medical records of 3024 mCRC patients were reviewed. Eligible cases undergoing potentially curative liver resection were selected. BRAF and RAS mutational status was tested on primary and/or metastases by means of pyrosequencing and mass spectrometry genotyping assay. Primary endpoint was relapse-free survival (RFS).In the final study population (N=309) BRAF mutant, RAS mutant and all wild-type (wt) patients were 12(4%), 160(52%) and 137(44%), respectively. Median RFS was 5.7, 11.0 and 14.4 months respectively and differed significantly (Log-rank, P=0.043). At multivariate analyses, BRAF mutant had a higher risk of relapse in comparison to all wt (multivariate hazard ratio (HR)=2.31; 95% CI, 1.09-4.87; P=0.029) and to RAS mutant (multivariate HR=2.06; 95% CI, 1.02-4.14; P=0.044). Similar results were obtained in terms of overall survival. Compared with all wt patients, RAS mutant showed a higher risk of death (HR=1.47; 95% CI, 1.05-2.07; P=0.025), but such effect was lost at multivariate analyses.BRAF mutation is associated with an extremely poor median RFS after liver resection and with higher probability of relapse and death. Knowledge of BRAF mutational status may optimise clinical decision making in mCRC patients potentially candidate to hepatic surgery. RAS status as useful marker in this setting might require further studies." @default.
• W2234830428 created "2016-06-24" @default.
• W2234830428 creator A5004814157 @default.
• W2234830428 creator A5013482646 @default.
• W2234830428 creator A5017474339 @default.
• W2234830428 creator A5019451531 @default.
• W2234830428 creator A5023227998 @default.
• W2234830428 creator A5026460566 @default.
• W2234830428 creator A5028325185 @default.
• W2234830428 creator A5029495871 @default.
• W2234830428 creator A5034356923 @default.
• W2234830428 creator A5044354358 @default.
• W2234830428 creator A5045419569 @default.
• W2234830428 creator A5047673996 @default.
• W2234830428 creator A5048141257 @default.
• W2234830428 creator A5049960947 @default.
• W2234830428 creator A5051613962 @default.
• W2234830428 creator A5053998173 @default.
• W2234830428 creator A5054413273 @default.
• W2234830428 creator A5068353710 @default.
• W2234830428 creator A5081985776 @default.
• W2234830428 creator A5090001130 @default.
• W2234830428 creator A5090671983 @default.
• W2234830428 date "2015-05-05" @default.
• W2234830428 modified "2023-10-06" @default.
• W2234830428 title "BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection" @default.
• W2234830428 cites W1538989751 @default.
• W2234830428 cites W1586939666 @default.
• W2234830428 cites W1597604324 @default.
• W2234830428 cites W1967628954 @default.
• W2234830428 cites W1970844261 @default.
• W2234830428 cites W1985645498 @default.
• W2234830428 cites W1988969830 @default.
• W2234830428 cites W1989175303 @default.
• W2234830428 cites W1998940725 @default.
• W2234830428 cites W2007220035 @default.
• W2234830428 cites W2007900522 @default.
• W2234830428 cites W2014449122 @default.
• W2234830428 cites W2029684529 @default.
• W2234830428 cites W2038202392 @default.
• W2234830428 cites W2061597882 @default.
• W2234830428 cites W2063985381 @default.
• W2234830428 cites W2064285571 @default.
• W2234830428 cites W2077428590 @default.
• W2234830428 cites W2084470612 @default.
• W2234830428 cites W2085633477 @default.
• W2234830428 cites W2100471896 @default.
• W2234830428 cites W2101815035 @default.
• W2234830428 cites W2106789440 @default.
• W2234830428 cites W2120331439 @default.
• W2234830428 cites W2121683205 @default.
• W2234830428 cites W2125500263 @default.
• W2234830428 cites W2134142320 @default.
• W2234830428 cites W2135800465 @default.
• W2234830428 cites W2140143664 @default.
• W2234830428 cites W2148633912 @default.
• W2234830428 cites W2149782431 @default.
• W2234830428 cites W2155311724 @default.
• W2234830428 cites W2158451494 @default.
• W2234830428 cites W2164837623 @default.
• W2234830428 cites W2165976417 @default.
• W2234830428 cites W2600018976 @default.
• W2234830428 doi "https://doi.org/10.1038/bjc.2015.142" @default.
• W2234830428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4580391" @default.
• W2234830428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25942399" @default.
• W2234830428 hasPublicationYear "2015" @default.
• W2234830428 type Work @default.
• W2234830428 sameAs 2234830428 @default.
• W2234830428 citedByCount "136" @default.
• W2234830428 countsByYear W22348304282015 @default.
• W2234830428 countsByYear W22348304282016 @default.
• W2234830428 countsByYear W22348304282017 @default.
• W2234830428 countsByYear W22348304282018 @default.
• W2234830428 countsByYear W22348304282019 @default.
• W2234830428 countsByYear W22348304282020 @default.
• W2234830428 countsByYear W22348304282021 @default.
• W2234830428 countsByYear W22348304282022 @default.
• W2234830428 countsByYear W22348304282023 @default.
• W2234830428 crossrefType "journal-article" @default.
• W2234830428 hasAuthorship W2234830428A5004814157 @default.
• W2234830428 hasAuthorship W2234830428A5013482646 @default.
• W2234830428 hasAuthorship W2234830428A5017474339 @default.
• W2234830428 hasAuthorship W2234830428A5019451531 @default.
• W2234830428 hasAuthorship W2234830428A5023227998 @default.
• W2234830428 hasAuthorship W2234830428A5026460566 @default.
• W2234830428 hasAuthorship W2234830428A5028325185 @default.
• W2234830428 hasAuthorship W2234830428A5029495871 @default.
• W2234830428 hasAuthorship W2234830428A5034356923 @default.
• W2234830428 hasAuthorship W2234830428A5044354358 @default.
• W2234830428 hasAuthorship W2234830428A5045419569 @default.
• W2234830428 hasAuthorship W2234830428A5047673996 @default.
• W2234830428 hasAuthorship W2234830428A5048141257 @default.
• W2234830428 hasAuthorship W2234830428A5049960947 @default.
• W2234830428 hasAuthorship W2234830428A5051613962 @default.
• W2234830428 hasAuthorship W2234830428A5053998173 @default.
• W2234830428 hasAuthorship W2234830428A5054413273 @default.
• W2234830428 hasAuthorship W2234830428A5068353710 @default.
• W2234830428 hasAuthorship W2234830428A5081985776 @default.

• next