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• W2234855060 abstract "It is a cause for some debate as to how the auditory olivocochlear (OC) efferent system could protect hearing from noise trauma. In this review, we examined physiological research to find mechanisms that could effectively attenuate the response to sound. For each purported mechanism, we indicate which part of the OC-efferent system is responsible for the function and the site of action. These mechanisms include basilar-membrane phase shifts at high stimulus levels; changes in outer-hair-cell stiffness and phase lag associated with efferent slow effects; small decreases in endocochlear potentials causing small decreases in outer- and inner-hair-cell output; low-spontaneous-rate and medium-spontaneous-rate fibers showing OC-induced decrements at high levels; auditory-nerve initial-peak reduction; OC effect increasing over minutes; cholinergic activation of anti-apoptotic pathways; and anti-excitotoxicity. There are clearly multiple opportunities for the OC-efferent system to protect the inner ear from noise trauma. From further exploration into the mechanisms outlined here, as well as to-be-discovered mechanisms, we will gain a greater understanding of the protective nature of the OC-efferent system. These findings could aid our ability to design better predictive tests for people at risk for noise-induced hearing loss." @default.
• W2234855060 created "2016-06-24" @default.
• W2234855060 creator A5035816257 @default.
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• W2234855060 date "2015-01-01" @default.
• W2234855060 modified "2023-10-17" @default.
• W2234855060 title "How can the auditory efferent system protect our ears from noise-induced hearing loss? Let us count the ways" @default.
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• W2234855060 doi "https://doi.org/10.1063/1.4939427" @default.
• W2234855060 hasPublicationYear "2015" @default.
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