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- W2234927031 abstract "Bioabsorbable materials enable temporary implantation without the need for subsequent implant removal. The aim of the present experimental study was to evaluate the suitability of a fibrous bioabsorbable implant made of poly-L/D-lactide (PLDLA) 96/4 fibres as an episcleral implant. The general tissue reactions were evaluated in subcutaneous tissues in rats in follow-up periods ranging from 3 days to 48 weeks. The episcleral tissue reactions were studied in rabbits with follow-up periods of one, three, five and 48 weeks. A silicone sponge implant was used as a control material and operations were performed using similar technique with both implants. Tissue reactions were located just around the implant area and consisted of an acute inflammatory reaction in the early follow-up periods, continuing as a foreign body inflammatory reaction. With episcleral implants there were no inflammatory cells seen within the sclera or in the retinal layers, and the structure of the retina and the cornea was also normal. The biocompatibility was good in the 48 week follow-up despite the relatively high surface area of the fibrous implant. The material had not degraded by 48 weeks. The indentation effect by the PLDLA implant (diameter of 3–3.5mm) was lower than that achieved with the silicone sponge implant (diameter 4mm). The depth of indentation decreased over time in both groups with comparable rates over the follow-up period of 5 months. The duration of the indentation effect was sufficient to be used for scleral buckling in retinal detachment surgery. In conclusion, the biocompatibility of a fibrous implant made of PLDLA 96/4 placed subcutaneously and episclerally was good in the follow-up lasting 48 weeks despite the relatively high surface area of the implant. The fibrous implant made of PLDLA 96/4 seemed to be welltolerated by ocular tissues and the indentation effect was sufficiently long." @default.
- W2234927031 created "2016-06-24" @default.
- W2234927031 creator A5036912189 @default.
- W2234927031 date "2009-01-01" @default.
- W2234927031 modified "2023-09-27" @default.
- W2234927031 title "Evaluation of bioabsorbable poly-L/D-lactide implant for scleral buckling : an experimental study" @default.
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