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- W2234985540 abstract "Among invasive Haemophilus influenzae, unencapsulated strains have largely surpassed the previously predominant serotype b (Hib) because of Hib vaccination. Isolates without the genomic capsule (cap) locus are designated non-typeable H. influenzae (NTHi). They are different from capsule-deficient variants that show deletion of the capsule transport gene bexA within the cap locus. The frequency of capsule-deficient variants in invasive disease is unknown. We analysed 783 unencapsulated invasive isolates collected over 5 years in Germany and found no single capsule-deficient isolate. Invasive unencapsulated strains in Germany were exclusively NTHi. A negative serotyping result by slide agglutination was therefore highly predictive for NTHi." @default.
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- W2234985540 date "2016-01-01" @default.
- W2234985540 modified "2023-09-27" @default.
- W2234985540 title "Analysis of non-typeable Haemophilus influenzae in invasive disease reveals lack of the capsule locus" @default.
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- W2234985540 doi "https://doi.org/10.1016/j.cmi.2015.09.027" @default.
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