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- W2235073421 endingPage "113" @default.
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- W2235073421 abstract "Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered as exogenous materials by mononuclear phagocytic system (MPS) cells, leading to passive accumulation in MPS-rich organs, such as liver, spleen and lung. Particle size, morphology and surface modification affect the biodistribution of nanocrystals. Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., top-down and bottom-up technologies." @default.
- W2235073421 created "2016-06-24" @default.
- W2235073421 creator A5013973657 @default.
- W2235073421 creator A5023925767 @default.
- W2235073421 creator A5051178495 @default.
- W2235073421 date "2016-03-01" @default.
- W2235073421 modified "2023-10-12" @default.
- W2235073421 title "Injected nanocrystals for targeted drug delivery" @default.
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- W2235073421 doi "https://doi.org/10.1016/j.apsb.2015.11.005" @default.
- W2235073421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4788714" @default.
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- W2235073421 hasPublicationYear "2016" @default.
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