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• W2235170711 startingPage "901" @default.
• W2235170711 abstract "Chemokine receptors are typically promiscuous, binding more than one ligand, with the ligands themselves often expressed in different spatial localizations by multiple cell types. This is normally a tightly regulated process; however, in a variety of inflammatory disorders, dysregulation results in the excessive or inappropriate expression of chemokines that drives disease progression. Biased agonism, the phenomenon whereby different ligands of the same receptor are able to preferentially activate one signaling pathway over another, adds another level of complexity to an already complex system. In this minireview, we discuss the concept of biased agonism within the chemokine family and report that targeting single signaling axes downstream of chemokine receptors is not only achievable, but may well present novel opportunities to target chemokine receptors, allowing the fine tuning of receptor responses in the context of allergic inflammation and beyond." @default.
• W2235170711 created "2016-06-24" @default.
• W2235170711 creator A5015425059 @default.
• W2235170711 creator A5036488639 @default.
• W2235170711 creator A5056641495 @default.
• W2235170711 date "2015-12-23" @default.
• W2235170711 modified "2023-10-16" @default.
• W2235170711 title "Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?" @default.
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• W2235170711 doi "https://doi.org/10.1189/jlb.2mr0815-392r" @default.
• W2235170711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26701135" @default.
• W2235170711 hasPublicationYear "2015" @default.
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