Matches in SemOpenAlex for { <https://semopenalex.org/work/W2235241419> ?p ?o ?g. }
- W2235241419 endingPage "629" @default.
- W2235241419 startingPage "617" @default.
- W2235241419 abstract "Very recent studies hold promise to reveal the role of stromal interaction molecule 1 (STIM1) in non-store-operated Ca2+ entry. Here we showed that in contrast to cytoplasmic membrane redistribution as previously noted, human umbilical vein endothelial STIM1 with a T-to-C nucleotide transition resulting in an amino acid substitution of leucine by proline in the signal peptide sequence translocated to perinuclear membrane upon intracellular Ca2+ depletion, amplified nucleoplasmic Ca2+ signaling through ryanodine receptor-dependent pathway, and enhanced the subsequent cAMP responsive element binding protein activity, matrix metalloproteinase-2 (MMP-2) gene expression, and endothelial tube forming. The abundance of mutated STIM1 and the MMP-2 expression were higher in native human umbilical vein endothelial cells of patients with gestational hypertension than controls and were significantly correlated with blood pressure. These findings broaden our understanding about structure-function bias of STIM1 and offer unique insights into its application in nucleoplasmic Ca2+, MMP-2 expression, endothelial dysfunction, and pathophysiological mechanism(s) of gestational hypertension." @default.
- W2235241419 created "2016-06-24" @default.
- W2235241419 creator A5001955231 @default.
- W2235241419 creator A5005999985 @default.
- W2235241419 creator A5034414842 @default.
- W2235241419 creator A5034708000 @default.
- W2235241419 creator A5056686459 @default.
- W2235241419 creator A5057768464 @default.
- W2235241419 creator A5069575202 @default.
- W2235241419 creator A5077361754 @default.
- W2235241419 date "2016-04-01" @default.
- W2235241419 modified "2023-10-15" @default.
- W2235241419 title "A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca2+ signaling" @default.
- W2235241419 cites W1526329149 @default.
- W2235241419 cites W1548458029 @default.
- W2235241419 cites W1585306115 @default.
- W2235241419 cites W1971042658 @default.
- W2235241419 cites W1978593035 @default.
- W2235241419 cites W1981364887 @default.
- W2235241419 cites W1984482377 @default.
- W2235241419 cites W1984593698 @default.
- W2235241419 cites W1986612276 @default.
- W2235241419 cites W1988523658 @default.
- W2235241419 cites W1994109113 @default.
- W2235241419 cites W1995782709 @default.
- W2235241419 cites W2001917660 @default.
- W2235241419 cites W2004386820 @default.
- W2235241419 cites W2016836925 @default.
- W2235241419 cites W2017583554 @default.
- W2235241419 cites W2022102237 @default.
- W2235241419 cites W2025066195 @default.
- W2235241419 cites W2026163884 @default.
- W2235241419 cites W2028226397 @default.
- W2235241419 cites W2028461366 @default.
- W2235241419 cites W2029839178 @default.
- W2235241419 cites W2032091955 @default.
- W2235241419 cites W2038589009 @default.
- W2235241419 cites W2041474455 @default.
- W2235241419 cites W2047612054 @default.
- W2235241419 cites W2054225000 @default.
- W2235241419 cites W2064063117 @default.
- W2235241419 cites W2064158585 @default.
- W2235241419 cites W2069811868 @default.
- W2235241419 cites W2077591858 @default.
- W2235241419 cites W2079071687 @default.
- W2235241419 cites W2080897541 @default.
- W2235241419 cites W2082849134 @default.
- W2235241419 cites W2086377497 @default.
- W2235241419 cites W2088412949 @default.
- W2235241419 cites W2088914212 @default.
- W2235241419 cites W2090533017 @default.
- W2235241419 cites W2098859322 @default.
- W2235241419 cites W2101586949 @default.
- W2235241419 cites W2109306505 @default.
- W2235241419 cites W2133466768 @default.
- W2235241419 cites W2142686640 @default.
- W2235241419 cites W2158652398 @default.
- W2235241419 cites W2169740154 @default.
- W2235241419 cites W2314100277 @default.
- W2235241419 cites W40002982 @default.
- W2235241419 cites W65332788 @default.
- W2235241419 doi "https://doi.org/10.1016/j.bbamcr.2016.01.007" @default.
- W2235241419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26775216" @default.
- W2235241419 hasPublicationYear "2016" @default.
- W2235241419 type Work @default.
- W2235241419 sameAs 2235241419 @default.
- W2235241419 citedByCount "7" @default.
- W2235241419 countsByYear W22352414192017 @default.
- W2235241419 countsByYear W22352414192018 @default.
- W2235241419 countsByYear W22352414192019 @default.
- W2235241419 countsByYear W22352414192020 @default.
- W2235241419 countsByYear W22352414192022 @default.
- W2235241419 countsByYear W22352414192023 @default.
- W2235241419 crossrefType "journal-article" @default.
- W2235241419 hasAuthorship W2235241419A5001955231 @default.
- W2235241419 hasAuthorship W2235241419A5005999985 @default.
- W2235241419 hasAuthorship W2235241419A5034414842 @default.
- W2235241419 hasAuthorship W2235241419A5034708000 @default.
- W2235241419 hasAuthorship W2235241419A5056686459 @default.
- W2235241419 hasAuthorship W2235241419A5057768464 @default.
- W2235241419 hasAuthorship W2235241419A5069575202 @default.
- W2235241419 hasAuthorship W2235241419A5077361754 @default.
- W2235241419 hasBestOaLocation W22352414191 @default.
- W2235241419 hasConcept C126322002 @default.
- W2235241419 hasConcept C134018914 @default.
- W2235241419 hasConcept C158617107 @default.
- W2235241419 hasConcept C162740809 @default.
- W2235241419 hasConcept C170493617 @default.
- W2235241419 hasConcept C202751555 @default.
- W2235241419 hasConcept C2777411675 @default.
- W2235241419 hasConcept C55493867 @default.
- W2235241419 hasConcept C62478195 @default.
- W2235241419 hasConcept C71924100 @default.
- W2235241419 hasConcept C86803240 @default.
- W2235241419 hasConcept C95444343 @default.
- W2235241419 hasConceptScore W2235241419C126322002 @default.
- W2235241419 hasConceptScore W2235241419C134018914 @default.
- W2235241419 hasConceptScore W2235241419C158617107 @default.