FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2235243555> ?p ?o ?g. }

• W2235243555 endingPage "e0004323" @default.
• W2235243555 startingPage "e0004323" @default.
• W2235243555 abstract "Ixodes scapularis is the most medically important tick species and transmits five of the 14 reportable human tick borne disease (TBD) agents in the USA. This study describes LC-MS/MS identification of 582 tick- and 83 rabbit proteins in saliva of I. scapularis ticks that fed for 24, 48, 72, 96, and 120 h, as well as engorged but not detached (BD), and spontaneously detached (SD). The 582 tick proteins include proteases (5.7%), protease inhibitors (7.4%), unknown function proteins (22%), immunity/antimicrobial (2.6%), lipocalin (3.1%), heme/iron binding (2.6%), extracellular matrix/ cell adhesion (2.2%), oxidant metabolism/ detoxification (6%), transporter/ receptor related (3.2%), cytoskeletal (5.5%), and housekeeping-like (39.7%). Notable observations include: (i) tick saliva proteins of unknown function accounting for >33% of total protein content, (ii) 79% of proteases are metalloproteases, (iii) 13% (76/582) of proteins in this study were found in saliva of other tick species and, (iv) ticks apparently selectively inject functionally similar but unique proteins every 24 h, which we speculate is the tick's antigenic variation equivalent strategy to protect important tick feeding functions from host immune system. The host immune responses to proteins present in 24 h I. scapularis saliva will not be effective at later feeding stages. Rabbit proteins identified in our study suggest the tick's strategic use of host proteins to modulate the feeding site. Notably fibrinogen, which is central to blood clotting and wound healing, was detected in high abundance in BD and SD saliva, when the tick is preparing to terminate feeding and detach from the host. A remarkable tick adaptation is that the feeding lesion is completely healed when the tick detaches from the host. Does the tick concentrate fibrinogen at the feeding site to aide in promoting healing of the feeding lesion? Overall, these data provide broad insight into molecular mechanisms regulating different tick feeding phases. These data set the foundation for in depth I. scapularis tick feeding physiology and TBD transmission studies." @default.
• W2235243555 created "2016-06-24" @default.
• W2235243555 creator A5021621194 @default.
• W2235243555 creator A5045900321 @default.
• W2235243555 creator A5057509206 @default.
• W2235243555 creator A5069076773 @default.
• W2235243555 creator A5074474672 @default.
• W2235243555 creator A5088838774 @default.
• W2235243555 creator A5089743274 @default.
• W2235243555 date "2016-01-11" @default.
• W2235243555 modified "2023-10-18" @default.
• W2235243555 title "Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding" @default.
• W2235243555 cites W147560895 @default.
• W2235243555 cites W1493102094 @default.
• W2235243555 cites W1515929155 @default.
• W2235243555 cites W1535820401 @default.
• W2235243555 cites W1551267694 @default.
• W2235243555 cites W1562768493 @default.
• W2235243555 cites W1565603180 @default.
• W2235243555 cites W1566912671 @default.
• W2235243555 cites W1905586680 @default.
• W2235243555 cites W1926303070 @default.
• W2235243555 cites W1930283217 @default.
• W2235243555 cites W1964911435 @default.
• W2235243555 cites W1965245063 @default.
• W2235243555 cites W1966047761 @default.
• W2235243555 cites W1966507802 @default.
• W2235243555 cites W1966513614 @default.
• W2235243555 cites W1967566515 @default.
• W2235243555 cites W1968261842 @default.
• W2235243555 cites W1968768356 @default.
• W2235243555 cites W1969355660 @default.
• W2235243555 cites W1970336275 @default.
• W2235243555 cites W1972168184 @default.
• W2235243555 cites W1973664534 @default.
• W2235243555 cites W1973744445 @default.
• W2235243555 cites W1975050432 @default.
• W2235243555 cites W1975309162 @default.
• W2235243555 cites W1975917092 @default.
• W2235243555 cites W1979229040 @default.
• W2235243555 cites W1981025988 @default.
• W2235243555 cites W1981440364 @default.
• W2235243555 cites W1981816138 @default.
• W2235243555 cites W1982440565 @default.
• W2235243555 cites W1982548251 @default.
• W2235243555 cites W1982739621 @default.
• W2235243555 cites W1982776158 @default.
• W2235243555 cites W1984225556 @default.
• W2235243555 cites W1984610550 @default.
• W2235243555 cites W1985314055 @default.
• W2235243555 cites W1985407614 @default.
• W2235243555 cites W1986562974 @default.
• W2235243555 cites W1986701745 @default.
• W2235243555 cites W1988031662 @default.
• W2235243555 cites W1988701970 @default.
• W2235243555 cites W1988738406 @default.
• W2235243555 cites W1990444531 @default.
• W2235243555 cites W1991303877 @default.
• W2235243555 cites W1993102294 @default.
• W2235243555 cites W1994470686 @default.
• W2235243555 cites W1995077546 @default.
• W2235243555 cites W2001328992 @default.
• W2235243555 cites W2002011866 @default.
• W2235243555 cites W2002031405 @default.
• W2235243555 cites W2005178146 @default.
• W2235243555 cites W2005762305 @default.
• W2235243555 cites W2006227359 @default.
• W2235243555 cites W2009038320 @default.
• W2235243555 cites W2009393104 @default.
• W2235243555 cites W2010695653 @default.
• W2235243555 cites W2010805937 @default.
• W2235243555 cites W2014508480 @default.
• W2235243555 cites W2014620450 @default.
• W2235243555 cites W2014697334 @default.
• W2235243555 cites W2016482598 @default.
• W2235243555 cites W2016993713 @default.
• W2235243555 cites W2018150196 @default.
• W2235243555 cites W2018156520 @default.
• W2235243555 cites W2018290030 @default.
• W2235243555 cites W2018788132 @default.
• W2235243555 cites W2020085213 @default.
• W2235243555 cites W2020136993 @default.
• W2235243555 cites W2022370671 @default.
• W2235243555 cites W2023010129 @default.
• W2235243555 cites W2025912594 @default.
• W2235243555 cites W2025979529 @default.
• W2235243555 cites W2026710095 @default.
• W2235243555 cites W2026794712 @default.
• W2235243555 cites W2029785731 @default.
• W2235243555 cites W2030206802 @default.
• W2235243555 cites W2032601646 @default.
• W2235243555 cites W2033545687 @default.
• W2235243555 cites W2035946377 @default.
• W2235243555 cites W2036580318 @default.
• W2235243555 cites W2036599675 @default.
• W2235243555 cites W2039330229 @default.
• W2235243555 cites W2040141270 @default.
• W2235243555 cites W2041680316 @default.

• next