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- W2235263910 endingPage "17" @default.
- W2235263910 startingPage "17" @default.
- W2235263910 abstract "Cutaneous melanoma is one of the most aggressive forms of skin cancer, and is correlated with a large proportion of skin cancer-related deaths. Therapy for cutaneous melanoma has advanced greatly through careful identification of therapeutic targets and the development of novel immunotherapeutic approaches. The identification of BRAF as well as other driver mutations, have allowed for a specialized approach to treatment. In addition, immune checkpoint inhibition has dramatically changed the treatment landscape over the past 5-10 years. The successful targeting of CTLA-4, as well as PD-1/PD-L1, has been translated into meaningful clinical benefit for patients, with multiple other potential agents in development. Systemic therapy for cutaneous melanoma is becoming more nuanced and often takes a multifaceted strategy. This review aims to discuss the benefits and limitations of current therapies in systemic melanoma treatment as well as areas of future development." @default.
- W2235263910 created "2016-06-24" @default.
- W2235263910 creator A5053539417 @default.
- W2235263910 creator A5090769354 @default.
- W2235263910 date "2016-01-15" @default.
- W2235263910 modified "2023-09-23" @default.
- W2235263910 title "Updates in Therapy for Advanced Melanoma" @default.
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- W2235263910 doi "https://doi.org/10.3390/cancers8010017" @default.
- W2235263910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4728464" @default.
- W2235263910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26784231" @default.
- W2235263910 hasPublicationYear "2016" @default.
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