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• W2235306881 abstract "The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress. However, the mechanism underlying both SIRT2 activation and regulation of the G2-to-M transition remains largely unknown. Here, we report the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2α) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A-Cdk2. Cyclin A-Cdk2 then phosphorylates SIRT2 at Ser331. This phosphorylation reduces SIRT2 catalytic activity and its binding affinity to centrosomes and mitotic spindles, promoting G2-to-M transition. We show that the inhibitory effect of cPLA2α on SIRT2 activity impacts various cellular processes, including cellular levels of histone H4 acetylated at K16 (Ac-H4K16) and Ac-α-tubulin. This regulatory effect of cPLA2α on SIRT2 defines a novel function of cPLA2α independent of its phospholipase activity and may have implications for the impact of SIRT2-related effects on tumorigenesis and age-related diseases." @default.
• W2235306881 created "2016-06-24" @default.
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• W2235306881 date "2015-11-01" @default.
• W2235306881 modified "2023-10-12" @default.
• W2235306881 title "Group IVA Cytosolic Phospholipase A₂ Regulates the G₂-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2" @default.
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• W2235306881 doi "https://doi.org/10.1128/mcb.00184-15" @default.
• W2235306881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589591" @default.
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