Matches in SemOpenAlex for { <https://semopenalex.org/work/W2235343790> ?p ?o ?g. }
- W2235343790 endingPage "487" @default.
- W2235343790 startingPage "475" @default.
- W2235343790 abstract "The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researchers with nuclease design, target site selection, and experimental validation. Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods. We also elucidate challenges in target selection, especially in predicting off-target effects, and discuss future directions in precision genome editing and its applications." @default.
- W2235343790 created "2016-06-24" @default.
- W2235343790 creator A5040434181 @default.
- W2235343790 creator A5044985085 @default.
- W2235343790 creator A5051621625 @default.
- W2235343790 creator A5056443935 @default.
- W2235343790 date "2016-03-01" @default.
- W2235343790 modified "2023-10-16" @default.
- W2235343790 title "Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing" @default.
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