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- W2235477396 abstract "Silica nanoparticles are versatile materials whose physicochemical surface properties can be precisely adjusted. Because it is possible to combine several functionalities in a single carrier, silica-based materials are excellent candidates for biomedical applications. However, the functionality of the nanoparticles can get lost upon exposure to biological media due to uncontrolled biomolecule adsorption. Therefore, it is important to develop strategies that reduce non-specific protein-particle interactions without losing the introduced surface functionality. Herein, organosilane chemistry is employed to produce magnetic silica nanoparticles bearing differing amounts of amino and alkene functional groups on their surface as orthogonally addressable chemical functionalities. Simultaneously, a short-chain zwitterion is added to decrease the non-specific adsorption of biomolecules on the nanoparticles surface. The multifunctional particles display reduced protein adsorption after incubation in undiluted fetal bovine serum as well as in single protein solutions (serum albumin and lysozyme). Besides, the particles retain their capacity to selectively react with biomolecules. Thus, they can be covalently bio-functionalized with an antibody by means of orthogonal click reactions. These features make the described multifunctional silica nanoparticles a promising system for the study of surface interactions with biomolecules, targeting, and bio-sensing." @default.
- W2235477396 created "2016-06-24" @default.
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- W2235477396 date "2016-01-01" @default.
- W2235477396 modified "2023-10-01" @default.
- W2235477396 title "Multifunctional clickable and protein-repellent magnetic silica nanoparticles" @default.
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- W2235477396 cites W1969285136 @default.
- W2235477396 cites W1972530499 @default.
- W2235477396 cites W1972856197 @default.
- W2235477396 cites W1973831032 @default.
- W2235477396 cites W1982044972 @default.
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- W2235477396 cites W1996844579 @default.
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- W2235477396 cites W2012407073 @default.
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- W2235477396 cites W2023744651 @default.
- W2235477396 cites W2028362286 @default.
- W2235477396 cites W2033699020 @default.
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- W2235477396 doi "https://doi.org/10.1039/c5nr08258g" @default.
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