FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2235505912> ?p ?o ?g. }

• W2235505912 endingPage "1354" @default.
• W2235505912 startingPage "1346" @default.
• W2235505912 abstract "The types of Ca(2+)-dependent K(+) channel involved in the prolonged afterhyperpolarization (AHP) in a subgroup of sympathetic neurons have been investigated in guinea pig celiac ganglia in vitro. The conductance underlying the prolonged AHP (gKCa2) was reduced to a variable extent in 100 nM apamin, an antagonist of SK-type Ca(2+)-dependent K(+) channels, and by about 55% in 20 nM iberiotoxin, an antagonist of BK-type Ca(2+)-dependent K(+) channels. The reductions in gKCa2 amplitude by apamin and iberiotoxin were not additive, and a resistant component with an amplitude of nearly 50% of control remained. These data imply that, as well as apamin- and iberiotoxin-sensitive channels, other unknown Ca(2+)-dependent K(+) channels participate in gKCa2. The resistant component of gKCa2 was not abolished by 0.5-10 mM tetraethylammonium, 1 mM 4-aminopyridine, or 5 mM glibenclamide. We also investigated which voltage-gated channels admitted Ca(2+) for the generation of gKCa2. Blockade of Ca(2+) entry through L-type Ca(2+) channels has previously been shown to reduce gKCa2 by about 40%. Blockade of N-type Ca(2+) channels (with 100 nM omega-conotoxin GVIA) and P-type Ca(2+) channels (with 40 nM omega-agatoxin IVA) each reduced the amplitude of gKCa2 by about 35%. Thus Ca(2+) influx through multiple types of voltage-gated Ca(2+) channel can activate the intracellular mechanisms that generate gKCa2. The slow time course of gKCa2 may be explained if activation of multiple K(+) channels results from Ca(2+) influx triggering a kinetically invariant release of Ca(2+) from intracellular stores located close to the membrane." @default.
• W2235505912 created "2016-06-24" @default.
• W2235505912 creator A5019506114 @default.
• W2235505912 creator A5021082772 @default.
• W2235505912 creator A5057824850 @default.
• W2235505912 date "2000-09-01" @default.
• W2235505912 modified "2023-10-18" @default.
• W2235505912 title "Diversity of Channels Involved in Ca²⁺Activation of K⁺Channels During the Prolonged AHP in Guinea-Pig Sympathetic Neurons" @default.
• W2235505912 cites W1490823147 @default.
• W2235505912 cites W1554812413 @default.
• W2235505912 cites W1555733423 @default.
• W2235505912 cites W1795948620 @default.
• W2235505912 cites W1827142872 @default.
• W2235505912 cites W1876408798 @default.
• W2235505912 cites W1901482215 @default.
• W2235505912 cites W1971255672 @default.
• W2235505912 cites W1975996573 @default.
• W2235505912 cites W1978896400 @default.
• W2235505912 cites W1979287010 @default.
• W2235505912 cites W1987369275 @default.
• W2235505912 cites W1987797147 @default.
• W2235505912 cites W1989712467 @default.
• W2235505912 cites W1998592605 @default.
• W2235505912 cites W2003961668 @default.
• W2235505912 cites W2004038371 @default.
• W2235505912 cites W2019260785 @default.
• W2235505912 cites W2020477012 @default.
• W2235505912 cites W2020814275 @default.
• W2235505912 cites W2022103979 @default.
• W2235505912 cites W2022313581 @default.
• W2235505912 cites W2028752842 @default.
• W2235505912 cites W2030518428 @default.
• W2235505912 cites W2033523926 @default.
• W2235505912 cites W2034734577 @default.
• W2235505912 cites W2035845442 @default.
• W2235505912 cites W2036257997 @default.
• W2235505912 cites W2042670053 @default.
• W2235505912 cites W2042979086 @default.
• W2235505912 cites W2043520867 @default.
• W2235505912 cites W2043762161 @default.
• W2235505912 cites W2050135503 @default.
• W2235505912 cites W2050561071 @default.
• W2235505912 cites W2059988936 @default.
• W2235505912 cites W2065707263 @default.
• W2235505912 cites W2079221784 @default.
• W2235505912 cites W2079453878 @default.
• W2235505912 cites W2080786780 @default.
• W2235505912 cites W2081370552 @default.
• W2235505912 cites W2081880339 @default.
• W2235505912 cites W2088093088 @default.
• W2235505912 cites W2090676343 @default.
• W2235505912 cites W2107728113 @default.
• W2235505912 cites W2113936437 @default.
• W2235505912 cites W2140207877 @default.
• W2235505912 cites W2155253574 @default.
• W2235505912 cites W2160559898 @default.
• W2235505912 cites W2170787296 @default.
• W2235505912 cites W2171864007 @default.
• W2235505912 cites W2172253704 @default.
• W2235505912 cites W2181516104 @default.
• W2235505912 cites W2185280366 @default.
• W2235505912 cites W2214138855 @default.
• W2235505912 cites W2266266770 @default.
• W2235505912 cites W2286538121 @default.
• W2235505912 cites W2400030997 @default.
• W2235505912 cites W2418335879 @default.
• W2235505912 cites W2431424997 @default.
• W2235505912 doi "https://doi.org/10.1152/jn.2000.84.3.1346" @default.
• W2235505912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10980007" @default.
• W2235505912 hasPublicationYear "2000" @default.
• W2235505912 type Work @default.
• W2235505912 sameAs 2235505912 @default.
• W2235505912 citedByCount "28" @default.
• W2235505912 countsByYear W22355059122012 @default.
• W2235505912 countsByYear W22355059122014 @default.
• W2235505912 countsByYear W22355059122015 @default.
• W2235505912 countsByYear W22355059122016 @default.
• W2235505912 countsByYear W22355059122018 @default.
• W2235505912 countsByYear W22355059122019 @default.
• W2235505912 crossrefType "journal-article" @default.
• W2235505912 hasAuthorship W2235505912A5019506114 @default.
• W2235505912 hasAuthorship W2235505912A5021082772 @default.
• W2235505912 hasAuthorship W2235505912A5057824850 @default.
• W2235505912 hasConcept C12554922 @default.
• W2235505912 hasConcept C149786707 @default.
• W2235505912 hasConcept C153461711 @default.
• W2235505912 hasConcept C170493617 @default.
• W2235505912 hasConcept C178790620 @default.
• W2235505912 hasConcept C181911157 @default.
• W2235505912 hasConcept C185592680 @default.
• W2235505912 hasConcept C18699975 @default.
• W2235505912 hasConcept C2776919887 @default.
• W2235505912 hasConcept C2778457506 @default.
• W2235505912 hasConcept C2779411790 @default.
• W2235505912 hasConcept C2780419564 @default.
• W2235505912 hasConcept C2780922449 @default.
• W2235505912 hasConcept C50254741 @default.
• W2235505912 hasConcept C519063684 @default.

• next