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- W2235558503 abstract "Publisher Summary This chapter presents a pulmonary Cryptococcus neoformans infection model in rats. In this method, the rats are infected under direct visualization of the larynx by using an otoscope without surgery. Male Fischer 344 rats obtained from the National Cancer Institute and ranging in weight from 150 to 250 grams are used in this model. The rats used in this model should be free of Mycoplasma pulmonis and cilia-associated respiratory bacillus, both of which can induce spontaneous pulmonary infection in rats and could interfere with the interpretation of pulmonary findings. The basic protocol involves the inoculation of C. neoformans cells directly into the lungs through the intubated trachea. This procedure is accomplished with an otoscope and provides a mechanism for direct pulmonary inoculation without the need for surgery to expose the trachea. The anesthetized rat is placed supine on the incline board with the head of the rat at the top of the incline. An otoscope is placed in the mouth of the rat, to visualize the trachea and vocal cords. Rats are then infected by placing a blunted spinal needle or an angiocath through the mouth into the trachea with the tip resting at a site distal to the vocal cords and injecting a suspension of yeast cells into the lungs. Rats infected in this manner recover quickly from the actual infection procedure. In the immunocompetent rat, inoculation of C. neoformans into the respiratory tract produces pulmonary infection with low levels of extrapulmonary dissemination." @default.
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- W2235558503 date "1999-01-01" @default.
- W2235558503 modified "2023-09-28" @default.
- W2235558503 title "Experimental Pulmonary Cryptococcus neoformans Infection in Rats" @default.
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- W2235558503 doi "https://doi.org/10.1016/b978-012775390-4/50222-0" @default.
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