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- W2235579757 startingPage "764" @default.
- W2235579757 abstract "Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in SMARCB1 (INI1, SNF5, BAF47) or, to a lesser extent, SMARCA4 (BRG1) of the SWItch/sucrose nonfermentable chromatin remodeling complex. Recent transcription and methylation profiling studies suggest the existence of molecular subgroups. Thus, at the root of these seemingly enigmatic tumors lies a network of factors related to epigenetic regulation, which is not yet completely understood. While conventional-type chemotherapy may have significant survival benefit for certain patients, it remains to be determined which patients will eventually prove resistant to chemotherapy and thus need novel therapeutic strategies. Elucidation of the molecular consequences of a disturbed epigenome has led to the identification of a series of transduction cascades, which may be targeted for therapy. Among these are the pathways of cyclin D1/cyclin-dependent kinases 4 and 6, Hedgehog/GLI1, Wnt/ß-catenin, enhancer of zeste homolog 2, and aurora kinase A, among others. Compounds specifically targeting these pathways or agents that alter the epigenetic state of the cell are currently being evaluated in preclinical settings and in experimental clinical trials for AT/RT." @default.
- W2235579757 created "2016-06-24" @default.
- W2235579757 creator A5001861945 @default.
- W2235579757 creator A5003479459 @default.
- W2235579757 creator A5023572421 @default.
- W2235579757 creator A5042661460 @default.
- W2235579757 creator A5068380379 @default.
- W2235579757 date "2016-01-10" @default.
- W2235579757 modified "2023-10-17" @default.
- W2235579757 title "Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies" @default.
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