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• W2235679942 abstract "AMP-activated protein kinase (AMPK) plays a critical role both in sensing and regulating cellular energy state. In experimental animals, its activation has been shown to reduce the risk of obesity and diabetes-related co-morbidities such as insulin resistance, the metabolic syndrome and atherosclerotic cardiovascular disease. However, in humans, AMPK activation alone often does not completely resolve these conditions. Thus, an improved understanding of AMPK action and regulation in metabolic and other diseases is needed. Herein, we provide a brief description of the enzymatic regulation of AMPK and review its role in maintaining energy homeostasis. We then discuss tissue-specific actions of AMPK that become distorted during such conditions as obesity, type 2 diabetes and certain cancers. Finally, we explore recent findings regarding the interactions of AMPK with mammalian target of rapamycin complex 1 and the lysosome and discuss how changes in these relationships during overnutrition may lead to AMPK dysfunction. A more thorough understanding of AMPK's molecular interactions during diseases of overnutrition may provide key insights for the development of AMPK-based combinatorial treatments for metabolic disease." @default.
• W2235679942 created "2016-06-24" @default.
• W2235679942 creator A5021199589 @default.
• W2235679942 creator A5057664281 @default.
• W2235679942 creator A5089198169 @default.
• W2235679942 date "2016-05-01" @default.
• W2235679942 modified "2023-10-01" @default.
• W2235679942 title "Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights" @default.
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• W2235679942 doi "https://doi.org/10.1016/j.metabol.2016.01.005" @default.
• W2235679942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4834453" @default.
• W2235679942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27085772" @default.
• W2235679942 hasPublicationYear "2016" @default.
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