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- W2235789265 abstract "As a group, myeloproliferative neoplasms affect an estimated 6–10 per 100,000 people [1]. Although many of the individual myeloproliferative neoplasms had been previously recognized clinical entities, it was Dameshek in 1950 that proposed the currently recognized concept of the myeloproliferative neoplasms as a group of similar entities united by poorly controlled proliferation of various hematopoietic elements [2]. With the exception of chronic myelogenous leukemia (CML), few additional advancements had been made, and other members of this group had largely continued to be defined by a combination of clinical and pathologic criteria until very recently. Continued advances in molecular diagnostic techniques and research into these entities have recently yielded additional insights into the pathobiology of the myeloproliferative neoplasms. Although much of the story remains to be told, these insights are now reflected in the way myeloproliferative neoplasms are diagnosed and classified. The 2008 WHO Classification [1] groups the myeloproliferative neoplasms largely according to their associated molecular abnormalities, many of which involve tyrosine kinases (see Table 7.1). CML is defined by the presence of the BCR–ABL1 fusion. The diagnosis of the other “classic” myeloproliferative neoplasms – polycythemia vera, essential thrombocythemia, and primary myelofibrosis – is greatly aided by the presence of JAK2 mutations or MPL mutations. Myeloproliferative neoplasms involving PDGFRA, PDGFRB, and FGFR1 have been defined as a group containing somewhat heterogeneous but also unifying clinicopathologic features." @default.
- W2235789265 created "2016-06-24" @default.
- W2235789265 creator A5071554403 @default.
- W2235789265 date "2010-07-19" @default.
- W2235789265 modified "2023-09-26" @default.
- W2235789265 title "Molecular Pathology of Myeloproliferative Neoplasms" @default.
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