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- W2235883067 abstract "(CD), and 18 (45%) had ulcerative colitis (UC). Remission was achieved by 14 (63.6%) of the CD and 12 (66.7%) of the UC patients, respectively. There were no differences in demographic and clinical characteristics or therapeutic protocols between the CD and UC groups. Similar TL were observed among patients who maintained remission (26/40, 4.7±6.0 μg/ml) and those with active disease (14/40, 3.7±5.9 μg/ml) (p=NS). Moreover, 10/26 patients who maintained stable remission were found with TL below 1 μg/ml (low TL). Considering the entire cohort, low TL was found in 17 patients, 6 of whom had positive anti-infliximab antibodies while 3/6 were in remission. Of note, 5/40 patients had gradual loss of response throughout their infusion cycle, and were found with relatively lower mean TL, in contrast to those who had maintained stable response throughout the dosing cycle (1.5±1.9 vs. 4.7±6.2 μg/ml, respectively p=0.03). Conclusions: While TL may serve to assess loss of response, no correlation was found between clinical response and random TL taken during long term schedule maintenance therapy. Larger cohorts are still needed to assess the long-term predictive value of TL." @default.
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- W2235883067 date "2012-05-01" @default.
- W2235883067 modified "2023-09-25" @default.
- W2235883067 title "Tu1268 Distribution of IgG4 Cells in Medically Refractory Patients With Inflammatory Bowel Disease" @default.
- W2235883067 doi "https://doi.org/10.1016/s0016-5085(12)63062-5" @default.
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