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- W2235895934 abstract "Objective To observe the effect of comlex TIANPU tablets(cTP) on the immune and hematopoietic function of radiation-injured mice.Methods One hundred and eight male ICR mice(aged 6 weeks) were involved in present study and randomly divided into normal control group,model control group,positive control group,and cTP high-,middle-and low-dose group(18 each).Mice in cTP high-,middle-and low-dose group were administratered intragastrically with 0.24,0.12 and 0.06g/kg cTP,respectively;in positive control group with 20mg/kg leucogen;while in normal and model control group with same amount of distilled water.All the animals were administratered once a day for 21d.The radiation injury model was then established by radiation of 3.0 Gy 60Co γ rays in all mice except those in normal control group,and the intragastric administration was continued for 10 days after radiation(till the end of the experiment).The lymphocyte transformation,phagocytosis of phagocytes and the peripheral leukocyte count were determined,and the colony forming unit-erythroid(CFU-E),burst forming unit-erythroid(BFU-E),CFU-granulocyte and macrophage(CFU-GM),CFU-megakaryocyte(CFU-Meg) and CFU-multipotential(CFU-Mix) in bone marrow were tested.Results After 3.0Gy 60Co γ rays radiation,the T and B lymphocyte transformation and phagocytosis of phagocytes of model control group decreased significantly compared with those of normal control group(P < 0.01),while cTP increased the lymphocyte transformation and phagocytosis of phagocytes of model mice.Moreover,compared with normal control group,the CFU-E,BFU-E,CFU-GM,CFU-Meg and CFU-Mix in bone marrow and peripheral leukocyte count of model control group decreased rapidly after 3.0Gy 60Co γ ray radiation(P < 0.01),while cTP promoted the recovery of leukocytes and increased the CFU-E,BFU-E,CFU-GM,CFU-Meg and CFU-Mix.Conclusion cTP has a forceful effect against the radiation-induced damage in a possible mechanism of enhancing the immune and hematopoietic function." @default.
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- W2235895934 date "2011-01-02" @default.
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- W2235895934 title "Effects of complex TIANPU tablets on immune and hematopoietic function of radiation-injured mice" @default.
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