Matches in SemOpenAlex for { <https://semopenalex.org/work/W2235940902> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2235940902 endingPage "270" @default.
- W2235940902 startingPage "255" @default.
- W2235940902 abstract "The use of anthracycline antibiotics in cancer chemotherapy is limited by their cardiotoxic qualities. For the evaluation of new derivatives animal model systems are required. Cardiomyopathy can be induced in rabbits and monkeys, but these models are too expensive for screening purposes. In rats, anthracycline antibiotics cause morphologic lesions of the heart muscle, but these are more difficult to demonstrate than in larger animals. However, significant changes of the heart function (electrocardiogram (ECG), cardiac output), the function of heart mitochondria (inhibition of electron transfer, uncoupling of oxidative phosphorylation and inhibition of Ca translocation) occur in a dose-related manner. Intraventricular conduction defect demonstrated in the ECG is one of the earliest and most consistent expressions of the cardiotoxic properties of anthracyclines. It was therefore used as primary screening parameter. The results of the screening of over 50 new anthracyclines has shown that the cardiotoxic properties vary considerably and that they are not closely related to the chemotherapeutic and the hematotoxic properties. Interesting structure-activity relationships were observed in a series of rubidazone derivatives substituted at the benzhydrazone part of the molecule." @default.
- W2235940902 created "2016-06-24" @default.
- W2235940902 creator A5021875680 @default.
- W2235940902 creator A5031784156 @default.
- W2235940902 creator A5045307900 @default.
- W2235940902 date "2015-04-16" @default.
- W2235940902 modified "2023-10-14" @default.
- W2235940902 title "Model Systems for Cardiotoxic Effects of Anthracyclines" @default.
- W2235940902 doi "https://doi.org/10.1159/000401489" @default.
- W2235940902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/348084" @default.
- W2235940902 hasPublicationYear "2015" @default.
- W2235940902 type Work @default.
- W2235940902 sameAs 2235940902 @default.
- W2235940902 citedByCount "61" @default.
- W2235940902 countsByYear W22359409022012 @default.
- W2235940902 countsByYear W22359409022015 @default.
- W2235940902 countsByYear W22359409022016 @default.
- W2235940902 countsByYear W22359409022019 @default.
- W2235940902 countsByYear W22359409022021 @default.
- W2235940902 countsByYear W22359409022022 @default.
- W2235940902 crossrefType "book-chapter" @default.
- W2235940902 hasAuthorship W2235940902A5021875680 @default.
- W2235940902 hasAuthorship W2235940902A5031784156 @default.
- W2235940902 hasAuthorship W2235940902A5045307900 @default.
- W2235940902 hasConcept C111566952 @default.
- W2235940902 hasConcept C121608353 @default.
- W2235940902 hasConcept C126322002 @default.
- W2235940902 hasConcept C2776694085 @default.
- W2235940902 hasConcept C2776802502 @default.
- W2235940902 hasConcept C2778198053 @default.
- W2235940902 hasConcept C2778233292 @default.
- W2235940902 hasConcept C2778797674 @default.
- W2235940902 hasConcept C501593827 @default.
- W2235940902 hasConcept C530470458 @default.
- W2235940902 hasConcept C55493867 @default.
- W2235940902 hasConcept C71924100 @default.
- W2235940902 hasConcept C86803240 @default.
- W2235940902 hasConcept C98274493 @default.
- W2235940902 hasConceptScore W2235940902C111566952 @default.
- W2235940902 hasConceptScore W2235940902C121608353 @default.
- W2235940902 hasConceptScore W2235940902C126322002 @default.
- W2235940902 hasConceptScore W2235940902C2776694085 @default.
- W2235940902 hasConceptScore W2235940902C2776802502 @default.
- W2235940902 hasConceptScore W2235940902C2778198053 @default.
- W2235940902 hasConceptScore W2235940902C2778233292 @default.
- W2235940902 hasConceptScore W2235940902C2778797674 @default.
- W2235940902 hasConceptScore W2235940902C501593827 @default.
- W2235940902 hasConceptScore W2235940902C530470458 @default.
- W2235940902 hasConceptScore W2235940902C55493867 @default.
- W2235940902 hasConceptScore W2235940902C71924100 @default.
- W2235940902 hasConceptScore W2235940902C86803240 @default.
- W2235940902 hasConceptScore W2235940902C98274493 @default.
- W2235940902 hasLocation W22359409021 @default.
- W2235940902 hasLocation W22359409022 @default.
- W2235940902 hasOpenAccess W2235940902 @default.
- W2235940902 hasPrimaryLocation W22359409021 @default.
- W2235940902 hasRelatedWork W1970724943 @default.
- W2235940902 hasRelatedWork W2011099982 @default.
- W2235940902 hasRelatedWork W2061630788 @default.
- W2235940902 hasRelatedWork W2089055004 @default.
- W2235940902 hasRelatedWork W2327904433 @default.
- W2235940902 hasRelatedWork W2362258224 @default.
- W2235940902 hasRelatedWork W2513036012 @default.
- W2235940902 hasRelatedWork W2559553852 @default.
- W2235940902 hasRelatedWork W3152612547 @default.
- W2235940902 hasRelatedWork W4284891551 @default.
- W2235940902 isParatext "false" @default.
- W2235940902 isRetracted "false" @default.
- W2235940902 magId "2235940902" @default.
- W2235940902 workType "book-chapter" @default.