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- W2235990187 abstract "Isosteric replacement of a methyl group by a halogen atom (bromine or iodine) in natural compounds often does not impair chemical or biological properties. Iodo and bromo aliphatic amino acid analogs have been synthesized and studied for possible use as pancreas localizing agents. Rather than using the short-lived gamma-emitting isotopes of bromine suitable for scanning, the /sup 14/C labeled compounds were prepared. The valine analog, ..beta..-bromo-..cap alpha..-aminobutyric acid, was synthesized from /sup 14/C L-threonine and its distribution was studied in rats. Contrary to expectations, this compound showed no pancreas uptake or any other amino acid behavior. The failure of this bromo for methyl substituted compound to be biologically active is rather surprising in view of the good match in physical properties and previous success in analog localization. Iodo analogs of leucine (..gamma..-iodo-..cap alpha..-aminopentanoic acid) and valine (..beta..-iodo-..cap alpha..-aminobutyric acid) have been prepared with /sup 125/I labels. These compounds proved to be quite unstable and were rapidly deiodinated. It is clear that these bromo and iodo analogs of aliphatic amino acids are not useful as pancreas localizing agents." @default.
- W2235990187 created "2016-06-24" @default.
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- W2235990187 date "1978-04-01" @default.
- W2235990187 modified "2023-09-23" @default.
- W2235990187 title "Labeling pharmaceuticals with radioactive isotopes. Final report, June 1, 1973--November 30, 1977. [/sup 14/C, /sup 125/I, rats]" @default.
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